Apolipoprotein AI levels are increased in part as a consequence of reduced catabolism in nephrotic rats.
Apolipoprotein AI levels are increased in part as a consequence of reduced catabolism in nephrotic rats.
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DOI：
10.1152/ajprenal.1995.268.3.f532
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发表时间：
1995-03
期刊：
影响因子：
--
通讯作者：
G. Kaysen;E. Hoye;H. Jones
中科院分区：
文献类型：
--
作者：
G. Kaysen;E. Hoye;H. Jones
Heymann肾炎(HN)大鼠的载脂蛋白AI(Apo AI)合成显著高于对照组(SD)。但HN组载脂蛋白AI分解率也明显低于SD组。我们使用保留在分解代谢部位的标记物--~(125)I-ApoAI酪胺纤维二糖高密度脂蛋白，在6只HN大鼠、7只阿霉素(Adria)肾病大鼠和6只对照SD大鼠中建立了ApoAI分解代谢降低的位置。尽管HN和Adria大鼠有显著的尿载脂蛋白AI，但三组大鼠的肾脏总载脂蛋白AI分解代谢和尿量损失是相同的。两组肾病患者皮肤载脂蛋白AI分解代谢均减少，约占载脂蛋白AI分解代谢减少的44%。因此，很大一部分载脂蛋白AI在正常雄性大鼠皮肤中被分解代谢。皮肤载脂蛋白AI分解代谢减少导致肾病大鼠血浆水平升高。
Apolipoprotein AI (apo AI) synthesis, measured as the turnover of 125I-labeled apo AI-labeled high-density lipoprotein (HDL), was increased significantly in rats with Heymann nephritis (HN) vs. control Sprague-Dawley (SD) rats. However, fractional apo AI catabolic rate was also significantly less in HN vs. SD. We used 125I-apo AI tyramine cellobiose HDL, a marker retained at the catabolic site, to establish where apo AI catabolism decreased in six HN rats, seven rats with adriamycin (Adria)-induced nephrosis, and six control SD. Total renal apo AI catabolism, plus urinary losses, were the same in all three groups, despite significant urinary apo AI in HN and Adria rats. Apo AI catabolism was reduced in skin in both nephrotic groups, accounting for approximately 44% of reduced in apo AI catabolism. Thus a significant fraction of apo AI is catabolized in skin of normal male rats. Reduced apo AI catabolism in skin contributes to increased plasma levels in nephrotic rats.