The phytochemical, EGCG, extends lifespan by reducing liver and kidney function damage and improving age-associated inflammation and oxidative stress in healthy rats
The phytochemical, EGCG, extends lifespan by reducing liver and kidney function damage and improving age-associated inflammation and oxidative stress in healthy rats
复制标题
植物化学物质 EGCG 通过减少健康大鼠的肝肾功能损伤并改善与年龄相关的炎症和氧化应激来延长寿命。
DOI：
10.1111/acel.12133
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发表时间：
2013-12-01
期刊：
影响因子：
7.8
通讯作者：
Sun, Changhao
中科院分区：
文献类型：
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作者：
Niu, Yucun;Na, Lixin;Sun, Changhao
众所周知，植物化学物质对人类有许多潜在的健康益处。本研究的目的是探讨长期摄入植物化学物质表没食子儿茶素没食子酸酯（EGCG）对健康大鼠的身体生长、疾病预防和寿命的影响。68只雄性断奶Wistar大鼠随机分为对照组和EGCG组。从断奶到死亡动态测定影响寿命的变量，如血压、血糖、血脂、炎症和氧化应激。对照组的中位寿命为92.5周。EGCG将中位寿命提高到105.0周，并使死亡延迟约8 - 12周。与0周时的水平相比，两组的血压、血糖和血脂均随年龄显著升高。然而，在整个生命周期中，两组之间这些变量没有差异。与0周相比，两组的炎症和氧化应激均随年龄显著增加，且EGCG组的血清以及肝和肾组织中的炎症和氧化应激显著降低。EGCG组的肝和肾功能损伤显著减轻。此外，EGCG降低了转录因子NF - κB的mRNA和蛋白质表达，并增加了沉默信息调节因子2同源蛋白1（SIRT1）和叉头框蛋白O3a（FOXO3a）的上游蛋白质表达。总之，EGCG通过激活长寿因子FoxO3a和SIRT1抑制NF - κB信号通路，减少肝和肾损伤，改善与年龄相关的炎症和氧化应激，从而延长健康大鼠的寿命。
It is known that phytochemicals have many potential health benefits in humans. The aim of this study was to investigate the effects of long-term consumption of the phytochemical, epigallocatechin gallate (EGCG), on body growth, disease protection, and lifespan in healthy rats. 68 male weaning Wistar rats were randomly divided into the control and EGCG groups. Variables influencing lifespan such as blood pressure, serum glucose and lipids, inflammation, and oxidative stress were dynamically determined from weaning to death. The median lifespan of controls was 92.5weeks. EGCG increased median lifespan to 105.0weeks and delayed death by approximately 8-12weeks. Blood pressure and serum glucose and lipids significantly increased with age in both groups compared with the levels at 0week. However, there were no differences in these variables between the two groups during the whole lifespan. Inflammation and oxidative stress significantly increased with age in both groups compared with 0week and were significantly lower in serum and liver and kidney tissues in the EGCG group. Damage to liver and kidney function was significantly alleviated in the EGCG group. In addition, EGCG decreased the mRNA and protein expressions of transcription factor NF-B and increased the upstream protein expressions of silent mating type information regulation two homolog one (SIRT1) and forkhead box class O 3a (FOXO3a). In conclusion, EGCG extends lifespan in healthy rats by reducing liver and kidney damage and improving age-associated inflammation and oxidative stress through the inhibition of NF-B signaling by activating the longevity factors FoxO3a and SIRT1.