Controversies and Criticisms on Designs for Experimental Autoimmune Labyrinthitis
Controversies and Criticisms on Designs for Experimental Autoimmune Labyrinthitis
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DOI：
10.1177/000348940411300512
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发表时间：
2004-05
期刊：
影响因子：
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通讯作者：
J. García-Berrocal;A. Trinidad;R. B. de la Fuente;R. Ramírez‐Camacho;M. Zurita;D. Lobo
中科院分区：
文献类型：
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作者：
J. García-Berrocal;A. Trinidad;R. B. de la Fuente;R. Ramírez‐Camacho;M. Zurita;D. Lobo
虽然免疫介导的内耳疾病在大约25年前就有报道，但已经进行了许多鉴定内耳抗原的尝试。实验动物模型已被用于研究听力损失的免疫机制和开发新的治疗方法。由于自身免疫性尿道炎的动物模型已经通过不同的抗原开发，我们还不能给出有效的免疫病理学解释。为了验证该方法，已经进行了更相关的实验模型的批判性分析。这些模型与自发性全身性自身免疫性疾病动物之间的比较提出了更多关于自身免疫性听力损失病理生理学的问题。提出了一种新的发病理论，涉及支持细胞的Corti器官。
Although immune-mediated inner ear disease was reported around 25 years ago, numerous attempts to identify the inner ear antigens have been performed. Experimental animal models have been used to study the immune mechanisms involved in hearing loss and to develop new therapies. Because animal models of autoimmune labyrinthitis have been developed by means of different antigens, we cannot yet show a valid immunopathologic explanation. A critical analysis of the more relevant experimental models employed has been performed in order to validate the methodology. Comparison between these models and animals with spontaneous systemic autoimmune disease has raised more questions concerning the pathophysiology of autoimmune hearing loss. A new pathogenetic theory is suggested, involving the supporting cells of the organ of Corti.