Effects of the hepatic lipase gene and physical activity on coronary heart disease risk
Effects of the hepatic lipase gene and physical activity on coronary heart disease risk
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DOI：
10.1093/aje/kwg230
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发表时间：
2003-11-01
影响因子：
5
通讯作者：
Hamman, RF
中科院分区：
文献类型：
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作者：
Hokanson, JE;Kamboh, MI;Hamman, RF
冠心病（CHD）有环境决定因素和遗传易感性;然而，确定改变遗传风险的因素一直很困难。有证据表明，肝脂酶基因（LIPC-480 C>T）的一个常见多态性可能与CHD的易感性有关，体力活动是与CHID相关的行为因素。这项在科罗拉多圣路易斯谷进行的基于人群的前瞻性研究调查了LIPC-480 C>T多态性在预测临床CHD和体力活动的调节作用中的作用。西班牙裔和非西班牙裔白人（n = 966）随访14年（1984-1998）;发生91例CHD事件。LIPC-480 TT基因型预测了两个种族中CHD的增加，体力活动改变了这种关系。在整个队列中，具有高危基因型和正常体力活动水平的受试者中冠心病的发病率显著升高（风险比= 2.58，95%置信区间：1.39，4.77），但在参加剧烈体力活动的高危基因型人群中没有升高（风险比= 0.52，95%置信区间：0.12，2.19）（参考组：LIPC-480 CC/CT;正常体力活动）。因此，在这项前瞻性队列研究中，LIPC-480 TT基因型仅在体力活动水平正常的受试者中增加了CHID的易感性，而在具有高风险基因型的剧烈活动受试者中则没有。
There are environmental determinants and genetic susceptibility to coronary heart disease (CHD); however, identifying factors that modify genetic risk has been difficult. Evidence suggests that a common polymorphism in the hepatic lipase gene (LIPC-480C>T) may be related to susceptibility to CHD and that physical activity is a behavioral factor associated with CHID. This population-based prospective study in the San Luis Valley of Colorado investigated the role of the LIPC-480C>T polymorphism in predicting clinical CHD and the modifying effect of physical activity. Hispanics and non-Hispanic Whites (n = 966) were followed for 14 years (1984-1998); 91 CHD events occurred. The LIPC-480 TT genotype predicted an increase in CHD in both ethnic groups, and physical activity altered this relation. In the full cohort, the rate of CHD was significantly elevated among subjects with the high-risk genotype and normal levels of physical activity (hazard ratio = 2.58, 95% confidence interval: 1.39, 4.77) but was not elevated among those with the high-risk genotype who participated in vigorous physical activity (hazard ratio = 0.52, 95% confidence interval: 0.12, 2.19) (reference group: LIPC-480 CC/CT; normal physical activity). Thus, in this prospective cohort study, the LIPC-480 TT genotype increased susceptibility to CHID only in those subjects with normal levels of physical activity, not in those with the high-risk genotype who were vigorously active.