Graphene-Montmorillonite Composite Sponge for Safe and Effective Hemostasis
Graphene-Montmorillonite Composite Sponge for Safe and Effective Hemostasis
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石墨烯-蒙脱石复合海绵安全有效止血
DOI：
10.1021/acsami.6b13302
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发表时间：
2016-12-28
影响因子：
9.5
通讯作者：
Wang, Xing
中科院分区：
文献类型：
--
作者：
Li, Guofeng;Quan, Kecheng;Wang, Xing
蒙脱石（MMT）是目前公认的天然层状硅酸盐中最有效的止血剂。但是，由于MMT粉末的侵入可能导致血管内血栓形成，因此，将MMT用于商业化的止血剂存在障碍。目前，如何管理好货币市场理论的释放，消除其负面效应，仍然是一个挑战。在此，我们提出了一种石墨烯-蒙脱土复合海绵（GMCS），在水热反应下合成，固定蒙脱土粉末到交联的石墨烯片。我们证明，只有少数嵌入的MMT可以在海绵界面引起显着的血小板刺激，同时保持先天海绵的快速血浆吸收性。在上述止血机制的协同作用下，GMCS在兔动脉损伤试验中可在约85 s内迅速止血。更重要的是，计算机断层扫描血管造影证明GMCS不会导致血管中的血栓或血凝块。细胞毒性试验进一步强调了其生物相容性。深入分析表明，二维石墨烯在复合材料结构中优于一维线性聚合物，血液分布的维度转换对增强止血性能起着至关重要的作用。这种GMCS止血剂不仅为石墨烯复合材料开辟了新的前景，也为粘土用于创伤治疗创造了新的机会。
Montmorillonite (MMT) is considered to be the most effective hemostat among natural phyllosilicates. However, there is a barrier against using MMT for the commercial hemostatics because the invaded MMT powders might cause thrombosis in vessel. Until now, it is still a challenge to manage the release of MMT and eliminate its side effect. Herein, we present a graphene-MMT composite sponge (GMCS), synthesized under a hydrothermal reaction, fixing MMT powders into the cross-linked graphene sheets. We demonstrate that only a few embedded MMT can evoke remarkable platelet stimulation at the sponge interface, while maintaining fast plasma absorbency of the innate sponge. In the synergy of the above hemostatic mechanisms, the GMCS can rapidly stop bleeding in approximately 85 s in rabbit artery injury test. More importantly, computed tomography angiography certifies that the GMCS does not cause thrombus or blood clot in vessels. Cytotoxicity assay further highlights its biocompatibility. In-depth analysis proposes that two-dimensional graphene overmatches one-dimensional linear polymers in the composite construction, and dimension transformation of blood distribution plays a crucial role for reinforcing the hemostatic performance. This GMCS hemostat not only opens a new perspective for graphene composite, but also makes a new chance of using clays for trauma therapy.