On the restricted mean survival time curve in survival analysis.
On the restricted mean survival time curve in survival analysis.
复制标题
在限制的生存分析中，平均生存时间曲线。
作者：
Zhao L;Claggett B;Tian L;Uno H;Pfeffer MA;Solomon SD;Trippa L;Wei LJ
对于以事件时间为终点的研究，其生存函数包含有关该结果变量的时间、随机概况的所有信息。然而，特定时间点的生存概率，比如t，并不能透明地捕捉到该端点到t的时间概况。另一种选择是使用时间t的限制平均生存时间（RMST）来总结概况。RMST是研究人群中随访到t的所有受试者的平均生存时间，简单地说就是生存曲线下到t的面积。在固定时间分析的背景下，已经讨论了使用这种量化方法相对于生存率的优势。在本文中，我们通过考虑基于RMST随时间变化的曲线作为生存函数的替代摘要来推广这种方法。例如，提出了基于单个RMST曲线的同时置信带和两个RMST曲线之间的差异的推断。后者为在等效或非劣效设置下评估两组提供信息，并在时间尺度上量化两组的差异。该建议是用两个临床试验的数据来说明的，一个来自肿瘤学，另一个来自心脏病学。
For a study with an event time as the endpoint, its survival function contains all the information regarding the temporal , stochastic profile of this outcome variable. The survival probability at a specific time point, say t, however, does not transparently capture the temporal profile of this endpoint up to t. An alternative is to use the restricted mean survival time (RMST) at time t to summarize the profile. The RMST is the mean survival time of all subjects in the study population followed up to t, and is simply the area under the survival curve up to t. The advantages of using such a quantification over the survival rate have been discussed in the setting of a fixed-time analysis. In this article, we generalize this approach by considering a curve based on the RMST over time as an alternative summary to the survival function. Inference, for instance, based on simultaneous confidence bands for a single RMST curve and also the difference between two RMST curves are proposed. The latter is informative for evaluating two groups under an equivalence or non-inferiority setting, and quantifies the difference of two groups in a time scale. The proposal is illustrated with the data from two clinical trials, one from oncology and the other from cardiology.