Emerging Trends in Flow Chemistry and Applications to the Pharmaceutical Industry
Emerging Trends in Flow Chemistry and Applications to the Pharmaceutical Industry
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DOI：
10.1021/acs.jmedchem.8b01760
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发表时间：
2019-07-25
影响因子：
7.3
通讯作者：
Dombrowski, Amanda W.
中科院分区：
文献类型：
--
作者：
Bogdan, Andrew R.;Dombrowski, Amanda W.
在过去的20年里，流动化学领域已经获得了相当大的关注。该观点强调了流动化学领域的许多最新进展，并讨论了从发现到制造的制药工业应用。从合成的角度来看，一些新的使能技术正在为在流动间歇技术中运行反应提供更多的理由。此外，高度自动化的流动合成平台已经开发出来，在整个制药行业具有广泛的适用性，从推进药物化学程序到自我优化合成路线。讨论了简化和自动化系统的组合，展示了如何定制流动化学解决方案以满足项目的特定需求。
The field of flow chemistry has garnered considerable attention over the past 2 decades. This Perspective highlights many recent advances in the field of flow chemistry and discusses applications to the pharmaceutical industry, from discovery to manufacturing. From a synthetic perspective, a number of new enabling technologies are providing more rationale to run reactions in flow over batch techniques. Additionally, highly automated flow synthesis platforms have been developed with broad applicability across the pharmaceutical industry, ranging from advancing medicinal chemistry programs to self-optimizing synthetic routes. A combination of simplified and automated systems is discussed, demonstrating how flow chemistry solutions can be tailored to fit the specific needs of a project.