Microbubble Generation in Phase-Shift Nanoemulsions used as Anticancer Drug Carriers.
Microbubble Generation in Phase-Shift Nanoemulsions used as Anticancer Drug Carriers.
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用作抗癌药物载体的相移纳米乳液中的微泡产生。
DOI：
10.1179/175889709x446516
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发表时间：
2009
期刊：
影响因子：
--
通讯作者：
Nam KH
中科院分区：
文献类型：
--
作者：
Rapoport NY;Efros AL;Christensen DA;Kennedy AM;Nam KH
本文描述了嵌段共聚物稳定的全氟戊烷纳米乳液的液滴到气泡的转变。评估了在液体乳剂和凝胶中触发液滴到气泡转变的三个物理因素，即热、超声波和通过细针注射。在列出的这些因素中，超声波辐射是最有效的因素。文中讨论的气泡生成和长大的可能机制包括：单个气泡内部的液-气转变；气泡合并；以及溶解空气和/或全氟戊烷从小气泡扩散到较大气泡(即奥斯瓦尔德成熟)。后两个因素导致液滴到气泡转变的不可逆性。在凝胶基质中，超声诱导的液滴到气泡的转变基本上被抑制，但被低频(数百千赫)超声波辐射的大(数百微米)预先存在的气泡催化。从理论上处理了液滴到气泡的转变与初始气泡尺寸的关系，并讨论了比表面积增大对气泡合并的促进作用。对观察到的效果的治疗意义进行了讨论。
The paper describes droplet-to-bubble transition in block copolymer stabilized perfluoropentane nanoemulsions. Three physical factors that trigger droplet-to-bubble transition in liquid emulsions and gels were evaluated, namely heat, ultrasound, and injections through fine-gauge needles. Among those listed, ultrasound irradiation was found the most efficient factor. Possible mechanisms of bubble generation and growth discussed in the paper include liquid-to-gas transition inside the individual bubble; bubble coalescence; and diffusion of dissolved air and/or perfluoropentane from small bubbles into larger bubbles (i.e., Oswald ripening). The last two factors result in irreversibility of the droplet-to-bubble transition. In gel matrices, ultrasound-induced droplet-to-bubble transition was substantially inhibited but was catalyzed by large (hundred micron) pre-existing bubbles irradiated by low frequency (hundred kilohertz) ultrasound. The dependence of the droplet-to-bubble transition on initial bubble size is theoretically treated and the role of increase of surface area in promoting bubble coalescence is discussed. Therapeutic implications of observed effects are discussed.