Iron-catalyzed nitrogen-directed coupling of arene and aryl bromides mediated by metallic magnesium
Iron-catalyzed nitrogen-directed coupling of arene and aryl bromides mediated by metallic magnesium
复制标题
DOI：
10.1002/adsc.201100791
复制
发表时间：
2012-03
影响因子：
5.4
通讯作者：
L. Ilies;Motoaki Kobayashi;A. Matsumoto;N. Yoshikai;E. Nakamura
中科院分区：
文献类型：
--
作者：
L. Ilies;Motoaki Kobayashi;A. Matsumoto;N. Yoshikai;E. Nakamura
2-芳基吡啶、2-烯基吡啶和芳香亚胺可在铁催化剂、金属镁、二胺配体和有机二卤化物氧化剂存在下与芳基溴在0℃下偶联。使用1:1的四氢呋喃和1,4-二氧六环的混合物对于这个CH键激活反应是必不可少的。与使用单独制备的格氏试剂的反应相比，该反应的底物范围更广，并且催化剂负载较低（2.5 mol%）。
2-Arylpyridines, 2-alkenylpyridine, and aromatic imines can be coupled with aryl bromides in the presence of an iron catalyst, metallic magnesium, a diamine ligand and an organic dihalide oxidant at 0 °C. The use of a 1:1 mixture of tetrahydrofuran and 1,4-dioxane is essential for this CH bond activation reaction. The reaction has wider scope of the substrate compared with the reaction using a separately prepared Grignard reagent, and proceeds with lower catalyst loading (2.5 mol%).