Morphine antinociception in different strains of mice: relationship of supraspinal-spinal multiplicative interaction to tolerance.
Morphine antinociception in different strains of mice: relationship of supraspinal-spinal multiplicative interaction to tolerance.
复制标题
不同品系小鼠的吗啡镇痛作用：脊髓上-脊髓乘性相互作用与耐受性的关系。
DOI：
--
复制
发表时间：
1988
影响因子：
3.5
通讯作者：
J. Fujimoto
中科院分区：
文献类型：
--
作者：
S. Roerig;J. Fujimoto
在大鼠和小鼠中，当侧脑室（i. c. v.）大脑和鞘内（i. t）在脊髓中，抗伤害感受反应发生倍增（协同）相互作用。在雄性Swiss考克斯小鼠中，随着对吗啡的高度全身耐受性的发展，这种倍增相互作用降低（变为相加），而i. c. v.或i.t.网站本身。本研究的目的是将这些结果在一个小鼠品系中扩展到其他品系，以确定这些结果如何普遍适用于吗啡耐受现象。在抗伤害性甩尾试验中使用8个不同品系的远系杂交小鼠以定量同时施用（i. c. v.和i.t.）与对全身（s.c.）施用的吗啡产生的耐受量有关。尽管s.c.吗啡在品系之间是相似的，但是通过植入吗啡丸3天而产生的耐受量是非常不同的（2-18倍）。一个关系被发现之间的耐受性发展到s.c.吗啡和倍增相互作用的变化（如通过i. c. v.加i.t.吗啡ED 50值）。在对照组动物中，I.T.在8个菌株中的6个菌株中产生了互作，而在剩余的2个菌株中显示了加性互作。吗啡丸植入3天后，在对s.c.吗啡（7-18倍），乘法相互作用降低为加法相互作用。（250字处删节）
In the rat and mouse when morphine is coadministered intracerebroventricularly (i.c.v.) in the brain and intrathecally (i.t.) in the spinal cord, a multiplicative (synergistic) interaction occurs for the antinociceptive response. In the male Swiss Cox mouse, with the development of a high degree of systemic tolerance to morphine, this multiplicative interaction decreases (becomes additive), whereas no change occurs in the ED50 for the i.c.v. or i.t. site itself. The purpose of the present study was to extend these findings in one mouse strain to other strains in order to determine how generally applicable such findings are to the phenomenon of tolerance to morphine. Eight different strains of outbred mice were used in the antinociceptive tail-flick test to quantify the multiplicative interaction of simultaneous administration (i.c.v. and i.t.) in relation to the amount of tolerance developed to morphine administered systemically (s.c.). Even though the control ED50 values for s.c. morphine were similar among strains, the amounts of tolerance developed by 3 days of implantation of a morphine pellet were very different (2-18-fold). A relationship was found between the degree of tolerance developed to s.c. morphine and changes in the multiplicative interaction (as reflected by changes in the i.c.v. plus i.t. morphine ED50 values). In control animals, a multiplicative i.c.v.-i.t. interaction was produced in six of the eight strains, whereas an additive interaction was shown in the remaining two strains. With 3 days of morphine pellet implantation, in three strains which developed a large amount of tolerance to s.c. morphine (7-18-fold), the multiplicative interaction decreased to an additive interaction.(ABSTRACT TRUNCATED AT 250 WORDS)