Interplay between myeloid-derived suppressor cells (MDSCs) and Th17 cells: foe or friend?
Interplay between myeloid-derived suppressor cells (MDSCs) and Th17 cells: foe or friend?
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骨髓源性抑制细胞 (MDSC) 和 Th17 细胞之间的相互作用：是敌还是友？
DOI：
10.18632/oncotarget.8204
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发表时间：
2016-06-07
期刊：
影响因子：
--
通讯作者：
Gong W
中科院分区：
文献类型：
--
作者：
Wen L;Gong P;Liang C;Shou D;Liu B;Chen Y;Bao C;Chen L;Liu X;Liang T;Gong W
髓源性抑制细胞（Myeloid-derived suppressor cells, MDSCs）和Th17细胞分别在癌症和自身免疫领域首次被发现。近年来，它们在感染性疾病和实体器官移植等其他生物学和病理条件下的活动也得到了探索。然而，MDSCs与Th17细胞之间的相互作用及其相互作用的机制仍然不清楚。本文综述并分析了MDSCs与Th17细胞之间的关系，两者都参与肿瘤、自身免疫性疾病、感染等疾病。在肿瘤中，肿瘤部位MDSCs的增加通常伴随着Th17细胞的积累。然而，它们的关系在不同的肿瘤中并不一致。在关节炎小鼠或类风湿性关节炎（RA）患者中，MDSCs的增加可以改善疾病症状，导致IL-17A基因表达和Th17细胞积累减少。此外，我们认为MDSCs与Th17细胞之间的相互作用主要是由细胞因子介导的。然而，这些机制需要进一步研究。确定它们相互作用的细节将提供对免疫网络的更好理解，并可能导致未来免疫治疗策略的发展。
Myeloid-derived suppressor cells (MDSCs) and Th17 cells were first discovered in the fields of cancer and autoimmunity, respectively. In recent years, their activities have been explored in other biological and pathological conditions, such as infective diseases and solid organ transplantation. However, the interplay between MDSCs and Th17 cells and the mechanism of their interaction remain obscure. This review summarized and analyzed the relationship between MDSCs and Th17 cells, both of which participate in tumor, autoimmune disease, infection and other conditions. In tumors, the increase in MDSCs at the tumor site is usually accompanied by the accumulation of Th17 cells. However, their relationship is inconsistent in different tumors. In arthritic mice or rheumatoid arthritis (RA) patients, an increase in MDSCs, which could ameliorate disease symptoms, causes decreased IL-17A gene expression and Th17 cells accumulation. Furthermore, we concluded that the interaction between MDSCs and Th17 cells is mainly mediated by cytokines. However, the mechanisms require further investigation. Determining the details of their interplay will provide a better understanding of immune networks and could lead to the development of immunotherapeutic strategies in the future.
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影响因子：
5.4
作者：
Arocena, Alfredo R.;Onofrio, Luisina I.;Gea, Susana
通讯作者：
Gea, Susana
影响因子：
64.8
作者：
Bettelli, E;Carrier, YJ;Kuchroo, VK
通讯作者：
Kuchroo, VK
癌症扩增的骨髓源性抑制细胞通过膜结合 TGF-β1 诱导 NK 细胞无反应。
影响因子：
4.4
作者：
Li, Hequan;Han, Yanmei;Cao, Xuetao
通讯作者：
Cao, Xuetao
影响因子：
20.3
作者：
Agaugue, Sophie;Carosella, Edgardo D.;Rouas-Freiss, Nathalie
通讯作者：
Rouas-Freiss, Nathalie
DOI：
10.4049/jimmunol.0902574
发表时间：
2010-03-01
期刊：
Journal of immunology (Baltimore, Md. : 1950)
影响因子：
--
作者：
He D;Li H;Yusuf N;Elmets CA;Li J;Mountz JD;Xu H
通讯作者：
Xu H