IL-17 in protective immunity to intracellular pathogens.
IL-17 in protective immunity to intracellular pathogens.
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DOI：
10.4161/viru.1.5.12862
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发表时间：
2010-09
期刊：
影响因子：
5.2
通讯作者：
Gopal R
中科院分区：
文献类型：
--
作者：
Khader SA;Gopal R
The identification of a new T cell subset referred to as T helper 17 (Th17) cells and its role in protective immunity against extracellular bacterial infections is well established. In contrast, initial studies suggested that the IL-23-IL-17 pathway was not required for protection against intracellular pathogens such as mycobacterial infections. However, recent studies demonstrate that Th17-IL-23 pathway may play a crucial role in protective immunity against other intracellular pathogens by regulating the innate and adaptive immune responses. The current outlook on the role of IL-23-IL-17 pathway in protective immunity to intracellular pathogens is discussed here.
