Tuning the Cytokine Responses: An Update on Interleukin (IL)-4 and IL-13 Receptor Complexes.
Tuning the Cytokine Responses: An Update on Interleukin (IL)-4 and IL-13 Receptor Complexes.
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DOI：
10.3389/fimmu.2018.00888
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发表时间：
2018
影响因子：
7.3
通讯作者：
Junttila IS
中科院分区：
文献类型：
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作者：
Junttila IS
白细胞介素（IL）-4和IL - 13是相关的细胞因子，可调节过敏性炎症的诸多方面。它们在调节淋巴细胞、髓样细胞和非造血细胞的反应中起重要作用。在T细胞中，IL - 4诱导初始CD4 T细胞分化为Th2细胞；在B细胞中，IL - 4驱动免疫球蛋白（Ig）类别转换为IgG1和IgE；在巨噬细胞中，IL - 4和IL - 13诱导巨噬细胞的替代激活。这篇综述简要探讨了这些细胞因子受体的功能形成。我将讨论配体/受体相互作用的结合动力学以及这些细胞因子的受体链在不同细胞类型中的表达；这两者都是解释这些细胞因子诱导细胞内信号传导和基因表达效率的关键因素。大约30年前，威廉（比尔）·E·保罗（William (Bill) E. Paul）对IL - 4开展的部分工作现已发展成为我们当前对基础免疫学和免疫反应理解的一个重要组成部分。关于IL - 4的这一知识在临床上的重要性日益增加，因为针对该细胞因子及其信号转导的治疗方法正在成为治疗过敏性疾病临床实践的一部分。仅仅阅读这篇简短综述的参考文献列表，人们就能体会到比尔在塑造我们对过敏性炎症病理生理学的理解，特别是IL - 4在此过程中的作用方面所做出的巨大贡献。
Interleukin (IL)-4 and IL-13 are related cytokines that regulate many aspects of allergic inflammation. They play important roles in regulating the responses of lymphocytes, myeloid cells, and non-hematopoietic cells. In T-cells, IL-4 induces the differentiation of naïve CD4 T cells into Th2 cells, in B cells, IL-4 drives the immunoglobulin (Ig) class switch to IgG1 and IgE, and in macrophages, IL-4 and IL-13 induce alternative macrophage activation. This review gives a short insight into the functional formation of these cytokine receptors. I will discuss both the binding kinetics of ligand/receptor interactions and the expression of the receptor chains for these cytokines in various cell types; both of which are crucial factors in explaining the efficiency by which these cytokines induce intracellular signaling and gene expression. Work initiated in part by William (Bill) E. Paul on IL-4 some 30 years ago has now grown into a major building block of our current understanding of basic immunology and the immune response. This knowledge on IL-4 has growing clinical importance, as therapeutic approaches targeting the cytokine and its signal transduction are becoming a part of the clinical practice in treating allergic diseases. Just by reading the reference list of this short review, one can appreciate the enormous input Bill has had on shaping our understanding of the pathophysiology of allergic inflammation and in particular the role of IL-4 in this process.