Does the proteome encode organellar pH?
Does the proteome encode organellar pH?
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DOI：
10.1016/j.febslet.2005.12.103
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发表时间：
2006-02-06
期刊：
影响因子：
3.5
通讯作者：
Rao, R
中科院分区：
文献类型：
--
作者：
Brett, CL;Donowitz, M;Rao, R
蛋白质组本身固有的信息可能使蛋白质能够在特定的区室中以促进其自身功能的水平缓冲pH。我们观察到，在酵母蛋白质组中计算的等电点的分布匹配实验得出的细胞器pH值估计在不同的亚细胞室。这提出了一个有趣的进化问题：蛋白质的p/和细胞器的pH值共同进化以优化功能吗？(c)2006年欧洲生物化学学会联合会。Elsevier B. V.出版，保留所有权利。
Inherent to the proteome itself, may be information that enables proteins to buffer pH at a level that promotes their own function within a specialized compartment. We observe that the distribution of computed isoelectric points in the yeast proteome matches experimentally derived organellar pH estimates across distinct subcellular compartments. This raises an interesting evolutionary question: did the p/ of proteins and the pH of organelles co-evolve to optimize function? (c) 2006 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.