Dextroamphetamine. Its cognitive and behavioral effects in normal and hyperactive boys and normal men.
Dextroamphetamine. Its cognitive and behavioral effects in normal and hyperactive boys and normal men.
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右旋苯丙胺。
DOI：
10.1001/archpsyc.1980.01780210091010
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发表时间：
1980
影响因子：
--
通讯作者：
E. Mikkelsen
中科院分区：
文献类型：
--
作者：
J. Rapoport;M. Buchsbaum;H. Weingartner;T. Zahn;C. Ludlow;E. Mikkelsen
采用双盲交叉设计，比较了单次口服硫酸右旋苯丙胺对正常和多动青春期前男孩以及正常大学年龄男性的运动活动、警惕性、学习和情绪的影响。两组男孩和男人都表现出运动活动减少，警觉性增加，服用兴奋剂后学习任务有所改善。这些男性报告说，他们感到兴奋，而男孩们报告说，在服用兴奋剂后，他们只感到“疲倦”或“不同”。目前尚不清楚这种对成人和儿童情绪影响的差异是由于不同的药物经验，报告影响的能力，还是真正的药理学年龄相关效应。虽然在这些不同的群体之间，药物对运动活动和警惕性的影响存在一些数量上的差异，但兴奋剂对正常和多动儿童和成人的作用似乎相似。
The effects of a single oral dose of dextroamphetamine sulfate on motor activity, vigilance, learning, and mood were compared for normal and hyperactive prepubertal boys and normal college-aged men using a double-blind crossover design. Both groups of boys and men showed decreased motor activity increased vigilance, and improvement on a learning task after taking the stimulant drug. The men reported euphoria, while the boys reported only feeling "tired# or "different# after taking the stimulant. It is not clear whether this difference in effect on mood between adults and children is due to differing experience with drugs, ability to report affect, or a true pharmacologic age-related effect. While there were some quantitative differences in drug effects on motor activity and vigilance between these different groups, stimulants appear to act similarly on normal and hyperactive children and adults.