Optimized 3D Magnetization-Prepared Rapid Acquisition of Gradient Echo: Identification of Thalamus Substructures at 3T
Optimized 3D Magnetization-Prepared Rapid Acquisition of Gradient Echo: Identification of Thalamus Substructures at 3T
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DOI：
10.3174/ajnr.a2705
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发表时间：
2011-12-01
影响因子：
3.5
通讯作者：
Klose, U.
中科院分区：
文献类型：
--
作者：
Bender, B.;Maenz, C.;Klose, U.
背景和目的：由于丘脑的亚结构在标准T1和T2加权MR图像上不可见，因此脑深部电刺激植入的计划依赖于立体定向图谱坐标。本工作的目标是测试是否优化的3D MPPEND协议可以描绘丘脑substructures.MATERIALS和METHODS：优化后的TI，以最大限度地提高灰质和白色物质之间的对比度，6名健康受试者进行了扫描，在31与优化的3D MPPEND。结果进行了比较与立体定向图谱，和2名专家读者丘脑解剖学培训确定了4个大丘脑核groups.RESULTS：有不同的图谱和由此产生的MR图像之间的高度一致性。丘脑前、外侧、内侧、后4个大核群均能被可靠地检出。结论：优化后的3D MPWE成像方案提高了丘脑的对比度，能够准确识别4个丘脑大核团，且阅片者之间的一致性较高。
BACKGROUND AND PURPOSE: Because the substructures of the thalamus are not visible on standard T1- and T2-weighted MR images, planning of deep brain stimulation implantation relies on stereotactic atlas coordinates. The goal of the present work was to test whether an optimized 3D MPRAGE protocol can depict thalamus substructures.MATERIALS AND METHODS: After optimization of the TI to maximize contrast between gray matter and white matter, 6 healthy subjects were scanned at 31 with the optimized 3D MPRAGE. The results were compared with stereotactic atlases, and 2 expert readers trained in thalamic anatomy identified the 4 large thalamic nuclei groups.RESULTS: There was a high agreement between the different atlases and the resulting MR images. The 4 large thalamic nuclei groups (anterior, lateral, medial, posterior) could be detected reliably. The inter-reader consistency on the size and location was 75%-92%.CONCLUSIONS: The optimized 3D MPRAGE protocol improves contrast in the thalamus, and the 4 large thalamic nuclei groups can be identified with high inter-reader agreement.