Estimation of nitric oxide as an inflammatory marker in periodontitis.
Estimation of nitric oxide as an inflammatory marker in periodontitis.
复制标题
一氧化氮作为牙周炎中的炎症标志物的估计。
DOI：
10.4103/0972-124x.55842
复制
发表时间：
2009-05
影响因子：
--
通讯作者：
Kumari, N Suchetha
中科院分区：
文献类型：
--
作者：
Menaka, K B;Ramesh, Amitha;Thomas, Biju;Kumari, N Suchetha
一氧化氮（NO）不仅在宿主防御和体内平衡中是重要的，而且它也被认为是有害的，并且已经涉及多种炎症和自身免疫性疾病的发病机制。NO在牙周病中的存在可能反映了负责疾病进展的骨吸收的额外介质的参与。本研究旨在探讨慢性牙周炎患者血清中NO水平的变化及其与牙周病严重程度的关系。60名受试者参加了这项研究，并被分为两组。通过Griess反应测定稳定的氧化代谢产物亚硝酸盐的积累来测定NO水平。结果表明，牙周炎患者血清中亚硝酸盐含量明显高于健康人。NO的产生在牙周病中增加，这将使我们能够了解其在疾病进展中的作用，并且选择性抑制NO可能在限制牙周炎的进展中具有治疗效用。
Nitric oxide (NO) is not only important in host defense and homeostasis but it is also regarded as harmful and has been implicated in the pathogenesis of a wide variety of inflammatory and autoimmune diseases. The presence of NO in periodontal disease may reflect the participation of an additional mediator of bone resorption responsible for disease progression. The aim of this study was to assess the level of NO in serum in chronic periodontitis, and correlate these levels with the severity of periodontal disease. Sixty subjects participated in the study and were divided into two groups. NO levels were assayed by measuring the accumulation of stable oxidative metabolite, nitrite with Griess reaction. Results showed subjects with periodontitis had significantly high nitrite in serum than healthy subjects. NO production is increased in periodontal disease, this will enable us to understand its role in disease progression and selective inhibition of NO may be of therapeutic utility in limiting the progression of periodontitis.