STRESS-INDUCED INHIBITION OF REPRODUCTIVE FUNCTIONS - ROLE OF ENDOGENOUS CORTICOTROPIN-RELEASING FACTOR
STRESS-INDUCED INHIBITION OF REPRODUCTIVE FUNCTIONS - ROLE OF ENDOGENOUS CORTICOTROPIN-RELEASING FACTOR
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DOI：
10.1126/science.3003907
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发表时间：
1986-02-07
期刊：
影响因子：
56.9
通讯作者：
VALE, W
中科院分区：
文献类型：
--
作者：
RIVIER, C;RIVIER, J;VALE, W
在成年去势雄性大鼠中，暴露于不可避免的间歇性电击抑制了黄体生成素释放的脉动模式，并显着降低其血浆浓度。促肾上腺皮质激素释放因子（CRF）拮抗剂α-螺旋绵羊CRF残基9至41逆转了应激的抑制作用。无论是其外周注射，也不是脑室内注射的无活性CRF类似物des-Glu 17 Arg 35绵羊CRF是有效的。这些结果表明，内源性CRF可能介导某些有害刺激对生殖的有害影响。
In the adult castrated male rat, exposure to inescapable, intermittent electroshocks inhibited the pulsatile pattern of luteinizing hormone release and markedly lowered its plasma concentrations. The central administration of the corticotropin-releasing factor (CRF) antagonist .alpha.-helical ovine CRF residues 9 to 41 reversed the inhibitory action of stress. Neither its peripheral injection, nor the intraventricular injection of the inactive CRF analog des-Glu17 to Arg35 ovine CRF was effective. These results suggest that endogenous CRF may mediate some deleterious effects of noxious stimuli on reproduction.