Attenuated intrinsic connectivity within cognitive control network among individuals with remitted depression: Temporal stability and association with negative cognitive styles.
Attenuated intrinsic connectivity within cognitive control network among individuals with remitted depression: Temporal stability and association with negative cognitive styles.
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DOI：
10.1002/hbm.23564
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发表时间：
2017-06
影响因子：
4.8
通讯作者：
Langenecker SA
中科院分区：
文献类型：
--
作者：
Stange JP;Bessette KL;Jenkins LM;Peters AT;Feldhaus C;Crane NA;Ajilore O;Jacobs RH;Watkins ER;Langenecker SA
许多患有重度抑郁症 (MDD) 的人都会经历认知功能障碍，包括认知控制受损和消极认知风格。对当前 MDD 个体的功能连接 MRI 研究记录了默认模式网络内和跨网络的静息态连接的改变。然而，迄今为止，还没有研究评估缓解性MDD（rMDD）中认知控制网络（CCN）内连通性受损的程度，也没有研究检查这种衰减随时间推移的时间稳定性。这代表了在理解稳定的、类似特质的抑郁症风险表型方面存在重大差距。在本研究中，使用 CCN 中的三个双侧种子（背外侧前额叶皮层、下顶叶小叶和背侧前扣带皮层）收集了 52 名未接受药物治疗的 rMDD 年轻人和 47 名人口统计匹配的健康对照者的静息态功能连接数据。 rMDD 个体中整个 CCN 内的平均连接性减弱，但随着时间的推移保持稳定和可靠，并且从右侧背外侧前额叶皮层和右顶下小叶到三个双侧 CCN 种子最为明显。 rMDD 中连接性的减弱似乎是 CCN 特有的，而不是代表其他网络中网络内一致性的减弱（例如，默认模式、显着性）。此外，CCN 内连通性减弱介导了 rMDD 状态与抑郁症认知风险因素之间的关系，包括沉思、悲观归因风格和消极自动思维。鉴于这些认知标记是已知的复发预测因素，这些结果表明 CCN 内连通性减弱可能代表抑郁症风险特征表型的生物标记。
Many individuals with major depressive disorder (MDD) experience cognitive dysfunction including impaired cognitive control and negative cognitive styles. Functional connectivity MRI studies of individuals with current MDD have documented altered resting-state connectivity within the default-mode network and across networks. However, no studies to date have evaluated the extent to which impaired connectivity within the cognitive control network (CCN) may be present in remitted MDD (rMDD), nor have studies examined the temporal stability of such attenuation over time. This represents a major gap in understanding stable, trait-like depression risk phenotypes. In the present study, resting-state functional connectivity data were collected from 52 unmedicated young adults with rMDD and 47 demographically-matched healthy controls, using three bilateral seeds in the CCN (dorsolateral prefrontal cortex, inferior parietal lobule, and dorsal anterior cingulate cortex). Mean connectivity within the entire CCN was attenuated among individuals with rMDD, was stable and reliable over time, and was most pronounced from the right dorsolateral prefrontal cortex and right inferior parietal lobule to the three bilateral CCN seeds. Attenuated connectivity in rMDD appeared to be specific to the CCN as opposed to representing attenuated within-network coherence in other networks (e.g., default-mode, salience). In addition, attenuated connectivity within the CCN mediated relationships between rMDD status and cognitive risk factors for depression, including ruminative brooding, pessimistic attributional style, and negative automatic thoughts. Given that these cognitive markers are known predictors of relapse, these results suggest that attenuated connectivity within the CCN could represent a biomarker for trait phenotypes of depression risk.