Point-mutational MspI and Ile-Val polymorphisms closely linked in the CYP1A1 gene: lack of association with susceptibility to lung cancer in a Finnish study population.
Point-mutational MspI and Ile-Val polymorphisms closely linked in the CYP1A1 gene: lack of association with susceptibility to lung cancer in a Finnish study population.
复制标题
点突变 MspI 和 Ile-Val 多态性与 CYP1A1 基因密切相关：芬兰研究人群中与肺癌易感性缺乏关联。
DOI：
--
复制
发表时间：
1992
期刊：
影响因子：
--
通讯作者：
H. Vainio
中科院分区：
文献类型：
--
作者：
A. Hirvonen;K. Husgafvel‐Pursiainen;A. Karjalainen;S. Anttila;H. Vainio
本研究共纳入87例肺癌患者、23例非癌性肺部疾病患者和121例健康对照，未发现CYP1A1基因MspI限制性片段长度多态性（RFLP）与肺癌风险之间存在相关性。在肺癌人群中，组织学类型、吸烟和职业史也被检查与肺癌风险增加的关系。在CYP1A1基因的MspI RFLP与这些变量之间没有发现任何关联。这与早先的一份报告的结果相反，该报告描述了日本人群中罕见的基因型m2m2与肺癌易感性之间的关联；但挪威的另一项研究没有发现这种联系。很明显，在北欧人群中，CYP1A1基因的MspI多态性并不表明个体对肺癌的易感性。我们还研究了最近在日本研究人群中与MspI限制性内切位点多态性密切相关的一个新的点突变。这种突变导致人类CYP1A1血红素结合区域的异亮氨酸-缬氨酸氨基酸替代。我们在我们的研究中获得了类似的连锁，因此日本和北欧的MspI RFLP结果之间的差异不能基于这两个点突变之间不同程度的连锁。
In this study of 87 lung cancer patients, 23 patients with lung disease other than cancer, and 121 healthy controls, no association was found between the MspI restriction fragment length polymorphism (RFLP) of the CYP1A1 gene and lung cancer risk. In the lung cancer population, histological type, smoking, and occupational histories were also examined with respect to increased lung cancer risk. No association was found between the MspI RFLP in the CYP1A1 gene and any of these variables. This is in contrast to the results of an earlier report describing an association between the rare genotype m2m2 and susceptibility to lung cancer in a Japanese population; but another study in Norway found no such association. It is evident that, in the Nordic population, MspI polymorphism in the CYP1A1 gene does not indicate individual susceptibility to lung cancer. We also studied a new point mutation which has recently been closely linked to the MspI restriction site polymorphism in a Japanese study population. This mutation results in an isoleucine-valine amino acid replacement in the heme binding region of human CYP1A1. We obtained a similar linkage in our study, so the discrepancy between the Japanese and the Nordic MspI RFLP findings cannot be based on a different degree of linkage between these two point mutations.
影响因子：
--
作者：
G. Pfeifer;A. Riggs
通讯作者：
G. Pfeifer;A. Riggs