The therapeutic potential of the mesenchymal stem cell secretome in ischaemic stroke.
The therapeutic potential of the mesenchymal stem cell secretome in ischaemic stroke.
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DOI：
10.1177/0271678x18776802
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发表时间：
2018-08
期刊：
影响因子：
--
通讯作者：
Allan SM
中科院分区：
文献类型：
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作者：
Cunningham CJ;Redondo-Castro E;Allan SM
间充质干细胞（MSC）作为中风的再生疗法具有巨大的潜力，导致脑缺血动物模型的修复和功能恢复增加。虽然最初假设细胞替代是MSC的重要作用机制，但焦点已转移到其旁分泌作用或所谓的“旁观者”效应。MSC分泌多种生长因子、趋化因子、细胞因子和细胞外囊泡，通常称为MSC分泌组。有证据表明MSC分泌组可以通过多种机制促进修复，包括防止细胞凋亡，调节炎症反应和促进内源性修复机制，如血管生成和神经发生。在这篇综述中，我们将讨论目前正在采用的体外方法，以推动MSC分泌组向更抗炎和再生表型。然后，我们将研究分泌体在脑缺血临床前模型中促进修复和改善恢复的作用。
Mesenchymal stem cells (MSCs) hold great potential as a regenerative therapy for stroke, leading to increased repair and functional recovery in animal models of cerebral ischaemia. While it was initially hypothesised that cell replacement was an important mechanism of action of MSCs, focus has shifted to their paracrine actions or the so called “bystander” effect. MSCs secrete a wide array of growth factors, chemokines, cytokines and extracellular vesicles, commonly referred to as the MSC secretome. There is evidence suggesting the MSC secretome can promote repair through a number of mechanisms including preventing cell apoptosis, modulating the inflammatory response and promoting endogenous repair mechanisms such as angiogenesis and neurogenesis. In this review, we will discuss the in vitro approaches currently being employed to drive the MSC secretome towards a more anti-inflammatory and regenerative phenotype. We will then examine the role of the secretome in promoting repair and improving recovery in preclinical models of cerebral ischaemia.