Model study on trapping of protein selenenic acids by utilizing a stable synthetic congener
Model study on trapping of protein selenenic acids by utilizing a stable synthetic congener
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利用稳定的合成同系物捕获蛋白质硒酸的模型研究
DOI：
10.1039/c9nj01072f
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发表时间：
2019
影响因子：
3.3
通讯作者：
Kei Goto
中科院分区：
文献类型：
--
作者：
Shohei Sase;Ryutaro Kimura;Ryosuke Masuda;Kei Goto
利用硒代半胱氨酸衍生的硒酸（Sec-SeOH）具有巨大的空腔结构的优势，开发了一种稳定的伯烷基取代的硒酸作为硒代半胱氨酸衍生的硒酸（Sec-SeOH）的合成模型。该模型化合物被成功地应用于硒酶活性中心生成的蛋白质Sec-SeOH与几种试剂的捕获反应的模型研究。
A stable primary-alkyl-substituted selenenic acid was developed as a synthetic model of selenocysteine–derived selenenic acid (Sec–SeOH) by taking advantage of a huge cavity-shaped substituent. The primary-alkyl model compound was successfully applied to model studies on the trapping reaction of protein Sec–SeOH generated in the active site of selenoenzymes with several reagents.