Comparison of Critical Drug-Drug Interaction Listings: The Department of Veterans Affairs Medical System and Standard Reference Compendia
Comparison of Critical Drug-Drug Interaction Listings: The Department of Veterans Affairs Medical System and Standard Reference Compendia
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DOI：
10.1038/clpt.2009.198
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发表时间：
2010-01-01
影响因子：
6.7
通讯作者：
Malone, D. C.
中科院分区：
文献类型：
--
作者：
Olvey, E. L.;Clauschee, S.;Malone, D. C.
本研究的目的是评估美国退伍军人事务部 (VA) 列出的“关键”药物相互作用 (DDI) 和两个标准药物相互作用概要之间的一致性。将 VA 定义的关键 DDI 列表与两个标准市售药典（Micromedex DRUG-REAX 和药物相互作用：分析和管理 (DIAM)）进行比较，以确定系统之间的一致性程度。在 VA 归类为关键的 982 个 DDI 中，只有 136 个 DDI (13.7%) 在所有三个系统中都被视为关键。我们的结论是，总体而言，纲要和 VA 系统之间的一致性较差。
The objective of this study was to evaluate the agreement among the US Department of Veterans Affairs (VA) listing of "critical" drug-drug interactions (DDIs) and two standard drug-interaction compendia. A list of critical DDIs, as defined by the VA, was compared with two standard commercially available compendia (Micromedex DRUG-REAX and Drug Interactions: Analysis and Management (DIAM)) in order to determine the level of agreement among the systems. Of 982 DDIs classified as critical by the VA, only 136 DDIs (13.7%) were considered critical in all three systems. Our conclusion was that, overall, there is poor agreement among the compendia and the VA system.