Dietary Restriction Attenuates Inflammation and Protects Mouse Skin from High-Dose Ultraviolet B Irradiation
Dietary Restriction Attenuates Inflammation and Protects Mouse Skin from High-Dose Ultraviolet B Irradiation
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饮食限制可减轻炎症并保护小鼠皮肤免受高剂量 UVB 照射
DOI：
10.1089/rej.2021.0022
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发表时间：
2022-05-17
影响因子：
2.6
通讯作者：
Tao，Si
中科院分区：
文献类型：
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作者：
Tang，Duozhuang;Wu，Jianying;Tao，Si
紫外线B （UVB）辐射可以影响皮肤疾病的发生，甚至加重皮肤疾病，从炎症性疾病到肿瘤性疾病。饮食限制（DR）是一种众所周知的疗法，可以延缓衰老相关的病理，我们和其他人都表明，它可以在各种情况下显著抑制炎症，包括在未受干扰和有压力的情况下。目前尚不清楚DR是否可以作为一种非药物因素来保护皮肤免受uvb引起的损伤。在这项研究中，我们在UVB照射前1周对小鼠进行30% DR （798.6 mJ/cm2）。值得注意的是，持续DR显著改善了uvb诱导的皮肤损伤和组织学变化，并显著减少了皮肤炎症反应。有趣的是，即使在放疗后24小时，给予利比妥饮食的小鼠也会再次引起炎症反应，并对皮肤造成明显的强烈损伤。总之，这项研究提供了第一个实验证据，证明DR可以有效地保护小鼠皮肤免受高剂量UVB辐射，如果可以转化为对人类有很大的影响。
Ultraviolet B (UVB) radiation may influence the occurrence or even worsen cutaneous disorders from inflammatory to neoplastic disorders. Dietary restriction (DR) is a well-known regimen that can retard aging-associated pathologies, and is shown by us and others that it can significantly inhibit inflammation under various conditions, including in both undisturbed and stressed settings. It is unknown whether DR could act as a nonpharmacological factor to protect skin against UVB-induced damage. In this study, we performed 30% DR to mice 1 week before UVB irradiation (798.6 mJ/cm2). Remarkably, continuous DR significantly ameliorated UVB-induced skin damage and histological changes, associated with a great reduction in the inflammatory responses in the skin. Intriguingly, refed DR mice withad libitumdiet even 24 hours postirradiation reinflamed the inflammatory responses and induced significantly strong damage to the skin. Together, this study provides the first experimental evidence that DR greatly protects mouse skin from high dose of UVB irradiation, which if translatable could have great implications in human beings.