EFFECTS OF THE ANTIPROGESTERONE RU-486 IN NORMAL WOMEN .2. ADMINISTRATION IN THE LATE FOLLICULAR PHASE
EFFECTS OF THE ANTIPROGESTERONE RU-486 IN NORMAL WOMEN .2. ADMINISTRATION IN THE LATE FOLLICULAR PHASE
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DOI：
10.1016/s0002-9378(87)80236-3
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发表时间：
1987-12-01
影响因子：
9.8
通讯作者：
LOBO, RA
中科院分区：
文献类型：
--
作者：
SHOUPE, D;MISHELL, DR;LOBO, RA
用具有抗孕酮受体活性的合成类固醇RU 486研究了孕酮对正常月经周期中期促性腺激素分泌动力学的影响。对6名正常骑车的女性进行了连续三个周期的跟踪。在每个周期中，从第10天开始采集血样，一直持续到月经。对照周期结束后，第10天至第17天口服RU 486 100 mg。患者在没有药物治疗的情况下进行后续治疗周期。当在月经中期前给予RU486时，黄体生成素高峰延迟15.0+-。2.1天后摄取最后一片药片，导致周期为40.6+-。2.6与28.0.+-。2.3天(p<；0.01)。在RU 486给药期间，当预计黄体生成素正常上升时，注意到黄体生成素/卵泡刺激素上升减弱，黄体生成素/卵泡刺激素上升并未跟随孕酮上升。在减弱的激增之后，黄体生成素/卵泡刺激素水平正常，孕酮正常上升。RU-486给药期间雌二醇水平下降，提示RU-486可能对卵巢有直接作用。
RU 486, a synthetic steroid with antiprogesterone receptor activity, was used to investigate the importance of progesterone on gonadotropin secretory dynamics in the midcycle of the normal menstrual cycle. Six normally cycling women were followed for three consecutive cycles. During each cycle, blood samples were obtained beginning on day 10 and continued until menses. After a control cycle, 100 mg RU 486 was given orally between days 10 and 17. The patients were followed for a posttreatment cycle with no medication. When RU 486 was given before the midcycle, the luteinizing hormone surge was delayed by 15.0 .+-. 2.1 days after ingestion of the last pill, resulting in cycles of 40.6 .+-. 2.6 compared with 28.0 .+-. 2.3 days (p < 0.01). During RU 486 administration and at the time a normal luteinizing hormone surge was anticipated, an attenuated luteinizing hormone/follicle-stimulating hormone surge was noted that was not followed by a rise in progesterone. After the attenuated surge a normal luteinizing hormone/follicle-stimulating hormone level occurred, with a normal rise in progesterone. Estradiol levels during RU 486 administration decreased during treatment, indicating a possible direct action of RU 486 on the ovary.