Burden of Middle East respiratory syndrome coronavirus infection in Saudi Arabia
Burden of Middle East respiratory syndrome coronavirus infection in Saudi Arabia
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DOI：
10.1016/j.jiph.2019.11.016
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发表时间：
2020-05-01
影响因子：
6.7
通讯作者：
Madani, Tariq A.
中科院分区：
文献类型：
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作者：
Al-Raddadi, Rajaa M.;Shabouni, Omaima, I;Madani, Tariq A.
中东呼吸综合征冠状病毒感染目前在沙特阿拉伯造成相当大的发病率和死亡率。了解其作为一种新出现的传染病的负担，对于制定适当的控制战略至关重要。在这项研究中，MERS-CoV的负担估计了2012年6月6日至2015年1月5日的31个月期间。患者总数为835例; 528例（63.2%）患者为男性，771例（92.3%）患者年龄≥ 25岁，210例（25.1%）患者为医护人员。共有751例（89.9%）患者需要住院治疗。发病至住院的中位时间为2天（四分位距，0-5）。中位住院时间为14天（IQR，6-27）。总病死率为43.1%。基本繁殖数为0.9。作为沙特人，非医疗保健工作者，年龄≥ 65岁与死亡率较高显著相关。总之，中东呼吸综合征冠状病毒感染在沙特阿拉伯造成了巨大的健康负担。(C)2019作者（S）由Elsevier Ltd代表沙特国王本阿卜杜勒阿齐兹健康科学大学出版。
MERS-coronavirus infection is currently responsible for considerable morbidity and mortality in Saudi Arabia. Understanding its burden, as an emerging infectious disease, is vital for devising appropriate control strategies. In this study, the burden of MERS-CoV was estimated over 31 months period from June 6, 2012 to January 5, 2015. The total number of patients was 835; 528 (63.2%) patients were male, 771 (92.3%) patients were >= 25 years of age, and 210 (25.1%) patients were healthcare workers. A total of 751 (89.9%) patients required hospitalization. The median duration between onset of illness and hospitalization was 2 days (interquartile range, 0-5). The median length of hospital stay was 14 days (IQR, 6-27). The overall case fatality rate was 43.1%. Basic reproductive number was 0.9. Being Saudi, non-healthcare workers, and age >= 65 years were significantly associated with higher mortality. In conclusion, MERS-CoV infection caused a substantial health burden in Saudi Arabia. (C) 2019 The Author( s). Published by Elsevier Ltd on behalf of King Saud Bin Abdulaziz University for Health Sciences.