Effect of taurine and potential interactions with caffeine on cardiovascular function
Effect of taurine and potential interactions with caffeine on cardiovascular function
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DOI：
10.1007/s00726-014-1708-0
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发表时间：
2014-03
期刊：
影响因子：
3.5
通讯作者：
S. Schaffer;K. Shimada;C. J. Jong;Takashi Ito;J. Azuma;Kyoko Takahashi
中科院分区：
文献类型：
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作者：
S. Schaffer;K. Shimada;C. J. Jong;Takashi Ito;J. Azuma;Kyoko Takahashi
能量饮料在成年人中流行的主要推动力是它们能够提高精神警觉性、改善身体表现和提供能量。然而，伴随着能量饮料使用量的指数级增长，国家毒物数据系统最近的病例报告和分析也引发了人们对能量饮料安全性的质疑。大多数安全问题都集中在能量饮料对心血管和中枢神经系统功能的影响上。尽管咖啡因过量的影响已得到广泛研究，但有关能量饮料其他活性成分与咖啡因之间潜在相互作用的信息却很少。经常被提及的与咖啡因相互作用的候选活性成分之一是 β-氨基酸牛磺酸。尽管牛磺酸被认为是人类有条件必需的营养素，并且被认为在多种人类疾病中发挥着关键作用，但评估牛磺酸作用的临床研究仍然有限。然而，根据有关咖啡因和牛磺酸之间可能相互作用的综述，我们得出结论，牛磺酸应该可以中和咖啡因过量的一些不良影响。欧盟食品科学委员会于 2003 年 3 月发表了一份报告，总结了其对能量饮料成分的潜在相互作用的调查，对此结论表示同意。在心血管水平上，他们得出的结论是，“如果咖啡因和牛磺酸之间存在任何相互作用，牛磺酸可能会减少咖啡因对心血管的影响。”尽管这些相互作用仍有待在人类中进一步研究，但牛磺酸的生理功能似乎与过量饮用含咖啡因-牛磺酸的饮料相关的不良心血管症状不一致。
The major impetus behind the rise in energy drink popularity among adults is their ability to heighten mental alertness, improve physical performance and supply energy. However, accompanying the exponential growth in energy drink usage have been recent case reports and analyses from the National Poison Data System, raising questions regarding the safety of energy drinks. Most of the safety concerns have centered on the effect of energy drinks on cardiovascular and central nervous system function. Although the effects of caffeine excess have been widely studied, little information is available on potential interactions between the other active ingredients of energy drinks and caffeine. One of the active ingredients often mentioned as a candidate for interactions with caffeine is the beta-amino acid, taurine. Although taurine is considered a conditionally essential nutrient for humans and is thought to play a key role in several human diseases, clinical studies evaluating the effects of taurine are limited. However, based on this review regarding possible interactions between caffeine and taurine, we conclude that taurine should neutralize several untoward effects of caffeine excess. In agreement with this conclusion, the European Union’s Scientific Committee on Food published a report in March 2003 summarizing its investigation into potential interactions of the ingredients in energy drinks. At the cardiovascular level, they concluded that “if there are any interactions between caffeine and taurine, taurine might reduce the cardiovascular effects of caffeine.” Although these interactions remain to be further examined in humans, the physiological functions of taurine appear to be inconsistent with the adverse cardiovascular symptoms associated with excessive consumption of caffeine–taurine containing beverages.