QUINOLINIC ACID LESION OF THE STRIATUM INDUCES IMPAIRMENT IN SPATIAL-LEARNING AND MOTOR-PERFORMANCE IN RATS
QUINOLINIC ACID LESION OF THE STRIATUM INDUCES IMPAIRMENT IN SPATIAL-LEARNING AND MOTOR-PERFORMANCE IN RATS
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DOI：
10.1016/0304-3940(93)90752-7
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发表时间：
1993-01-12
影响因子：
2.5
通讯作者：
SCHWARZ, M
中科院分区：
文献类型：
--
作者：
BLOCK, F;KUNKEL, M;SCHWARZ, M
将喹啉酸（QA）注射到大鼠纹状体中，已知会产生与亨廷顿氏病（HD）相似的神经病理和神经化学改变。HD患者的一个临床特征是认知障碍。在立体定向注射240 nmol或溶剂后2周，采用Morris水迷宫测试大鼠的空间学习能力。QA损伤的动物需要更多的时间来找到隐藏的平台。与对照组相比，所有试验的游泳速度都有所降低。QA损伤大鼠游泳距离本身变长，沿侧壁游泳距离明显增加。目前的研究结果表明，纹状体的QA损伤导致运动能力和空间学习能力的缺陷。
Injection of quinolinic acid (QA) into the striatum of rats is known to produce neuropathological and neurochemical alterations similar to those observed in Huntington's disease (HD). One clinical feature of HD patients is cognitive impairment. Two weeks after stereotaxic injection of either QA (240 nmol) or solvent in rats spatial learning was tested in the Morris water maze. QA lesioned animals required more time to find the hidden platform. The swim speed was reduced in all trials compared to the controls. The swim distance itself was longer and the amount of swim distance along the side wall was significantly higher in QA lesioned rats. The present results suggest that QA lesion of the striatum leads to deficit in motor performance and in spatial learning.