Variation in mammographic breast density by race
Variation in mammographic breast density by race
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DOI：
10.1016/s1047-2797(00)00225-8
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发表时间：
2001-05-01
影响因子：
5.6
通讯作者：
Taplin, S
中科院分区：
文献类型：
--
作者：
El-Bastawissi, AY;White, E;Taplin, S
目的：由于观察到患乳腺癌风险的种族差异，作者进行了一项研究，以确定乳腺密度的变化，乳腺密度是乳腺癌风险的强预测因子，按种族和年龄划分。方法：研究对象是华盛顿州西雅图普吉特湾团体健康合作社的女性，年龄为 20-79 岁，在 96 年 6 月 1 日至 97 年 8 月 1 日之间进行了乳房 X 光检查。将乳房密度增加的女性（BI-RADS“不均匀致密”和“极其致密”）（n = 14,178）与脂肪乳房的女性（BI-RADS“几乎完全是脂肪”和“分散的纤维腺组织”）（n = 14,323）进行比较。使用 Logistic 回归来调整年龄、产次、首次生育年龄、绝经状态、目前使用的激素替代疗法和体重指数。 结果：对于亚洲女性和白人女性而言，致密乳房与脂肪乳房的比值比 (OR) 从 1.2 增加 [95% 置信区间 (CI) 0.9-1.6]。
PURPOSE: Because of the observed racial differences in risk of developing breast cancer, the authors conducted a study to determine the variation in breast density, a strong predictor of breast cancer risk, by race and age.METHODS: Study subjects were women enrolled in Group Health Cooperative of Puget Sound, Seattle, WA, aged 20-79 years, who had a screening mammogram between 6/1/96 and 8/1/97. Women with increased breast density (BI-RADS "heterogeneously dense" and "extremely dense") (n = 14,178) were compared to those with fatty breasts (BI-RADS "almost entirely fat" and "scattered fibroglandular tissue") (n = 14,323). Logistic regression was used with adjustment for age, parity, age at first birth, menopausal status, current use of hormone replacement therapy, and body mass index.RESULTS: The odds ratio (OR) for having dense breasts versus fatty breasts, comparing Asian to White women, increased from 1.2 [95% confidence interval (CI) 0.9-1.6] for women age