Visuotopic organization of macaque posterior parietal cortex: a functional magnetic resonance imaging study.
Visuotopic organization of macaque posterior parietal cortex: a functional magnetic resonance imaging study.
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DOI：
10.1523/jneurosci.3334-10.2011
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发表时间：
2011-02-09
期刊：
影响因子：
--
通讯作者：
Kastner S
中科院分区：
文献类型：
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作者：
Arcaro MJ;Pinsk MA;Li X;Kastner S
猕猴的解剖学和生理学研究表明，后顶叶皮层（PPC）存在多个视觉区域。虽然PPC神经元的许多响应特性已经被探索，但对PPC的大规模功能地形-特别是与视位组织相关的功能地形知之甚少。在清醒猕猴的3T高分辨率功能磁共振成像（fMRI）和相位编码的视网膜定位范式中，发现了沿V3a区前部PPC外侧部分延伸到外侧顶叶内沟（LIP）的大规模视觉定位组织。我们在尾侧PPC中发现了V3a前的两个新的视野图，称为CIP-1和CIP-2。CIP-1的极角表示从靠近上垂直子午线的区域（即与V3a和DP的共享边界）延伸到较低视野范围内的区域（即与CIP-2的共享边界）。CIP-2中的极角表示是CIP-1表示的镜像反转。CIP-1和CIP-2在外侧边界共享一个中央空间的表示。在CIP-2前方，在LIP内发现第三极角表征，称为视位性LIP （LIPvt）。LIP的极角表示从靠近上垂直子午线的区域（即与CIP-2共享的边界）扩展到靠近下垂直子午线的区域。中央视觉空间的表征在LIP的背侧部分被识别，周围表征在腹侧部分。我们还考虑在猕猴PPC中发现的地形大规模组织相对于在人类PPC中观察到的组织。
Macaque anatomy and physiology studies have revealed multiple visual areas in posterior parietal cortex (PPC). While many response properties of PPC neurons have been probed, little is known about PPC’s large-scale functional topography — specifically related to visuotopic organization. Using high-resolution functional magnetic resonance imaging (fMRI) at 3T with a phase–encoded retinotopic mapping paradigm in the awake macaque, a large-scale visuotopic organization along lateral portions of PPC anterior to area V3a and extending into the lateral intraparietal sulcus (LIP) was found. We identify two new visual field maps anterior to V3a within caudal PPC, referred to as CIP-1 and CIP-2. The polar angle representation in CIP-1 extends from regions near the upper vertical meridian (that is the shared border with V3a and DP) to those within the lower visual field (that is the shared border with CIP-2). The polar angle representation in CIP-2 is a mirror reversal of the CIP-1 representation. CIP-1 and CIP-2 share a representation of central space on the lateral border. Anterior to CIP-2, a third polar angle representation was found within LIP, referred to as visuotopic LIP (LIPvt). The polar angle representation in LIP extends from regions near the upper vertical meridian (that is the shared border with CIP-2) to those near the lower vertical meridian. Representations of central visual space were identified within dorsal portions of LIP with peripheral representations in ventral portions. We also consider the topographic large-scale organization found within macaque PPC relative to that observed in human PPC.