Honeysuckle anthocyanin supplementation prevents diet-induced obesity in C57BL/6 mice.
Honeysuckle anthocyanin supplementation prevents diet-induced obesity in C57BL/6 mice.
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DOI：
10.1039/c3fo60251f
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发表时间：
2013-10
期刊：
影响因子：
6.1
通讯作者：
Tao Wu;Zhuo-ping Yu;Qiong Tang;Haizhao Song;Zichun Gao;Wei Chen;Xiaodong Zheng
中科院分区：
文献类型：
--
作者：
Tao Wu;Zhuo-ping Yu;Qiong Tang;Haizhao Song;Zichun Gao;Wei Chen;Xiaodong Zheng
本研究探讨了金银花花青素（HA）在高脂饮食诱导小鼠模型中的抗肥胖作用。小鼠最初以低脂饮食（LFD）或高脂饮食（HFD）喂养8周。之后，将HFD喂养的小鼠分为5组，每组12只，包括HFD组、HFD +奥利司他组和HFD + HA（剂量为50、100、200 mg kg(-1)）组，再进行8周的实验。100或200 mg kg（-1）的透明质酸可以抑制体重增加，降低血清和肝脏脂质谱，改善肝功能受损，显著提高血清脂联素浓度，同时降低血清胰岛素和瘦素水平。这些结果表明，透明质酸的抗肥胖作用可能是通过阻断脂质积累。
This study investigated the anti-obesity effects of honeysuckle anthocyanins (HA) in a high fat diet-induced mouse model. The mice were initially fed with a low-fat diet (LFD) or high-fat diet (HFD) for 8 weeks. After that, the HFD-fed mice were divided into five groups, with 12 mice in each group, including a HFD group, a HFD plus Orlistat group, and three HFD plus HA (at a dose of 50, 100, or 200 mg kg(-1)) groups, for another 8-week experiment. HA at 100 or 200 mg kg(-1) can suppress body weight gain, reduce serum and liver lipid profiles, ameliorate impaired hepatic function, and significantly increase serum adiponectin concentration while decreasing serum insulin and leptin levels. These results suggest that the anti-obesity effect of HA might be through the blockage of lipid accumulation.