Adaptive responses of rats to prolonged treatment with epinephrine.
Adaptive responses of rats to prolonged treatment with epinephrine.
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大鼠对肾上腺素长期治疗的适应性反应。
DOI：
10.1152/ajpcell.1981.241.1.c55
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发表时间：
1981
期刊：
影响因子：
--
通讯作者：
Holloszy,JO
中科院分区：
文献类型：
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作者：
Fell,RD;Terblanche,SE;Winder,WW;Holloszy,JO
大鼠每天注射L-肾上腺素100 μ g/100 g体重，连续6周。肾上腺素处理的动物的心脏较重（11.5%），血糖和血浆胰岛素浓度低于对照组大鼠。比较两组对肾上腺素的急性反应。两组均出现血糖升高和血浆胰岛素、肝糖原和肌糖原降低。这些反应的幅度在两组中相似，除了肌糖原的减少，慢性肾上腺素治疗组的减少较小。肾上腺素治疗6周后，呼吸能力、柠檬酸合酶或琥珀酸脱氢酶活性或骨骼肌细胞色素c浓度均无变化。这些结果是兼容的建议，儿茶酚胺可能发挥了作用，在一些代谢和心脏适应运动训练。然而，他们强烈反对这样的假设，即儿茶酚胺是负责诱导增加肌肉线粒体发生在运动训练的反应。
Rats were given a daily injection of L-epinephrine, 100 micrograms/100 g body wt, for 6 wk. The hearts of the epinephrine-treated animals were heavier (11.5%), and blood glucose and plasma insulin concentrations were lower than those of control rats. Acute responses to epinephrine were compared in the two groups. An increase in blood glucose and decreases in plasma insulin, liver glycogen, and muscle glycogen occurred in both groups. The magnitude of these responses were similar in the two groups except for the decrease in muscle glycogen, which was smaller in the chronic epinephrine-treatment group. There were no changes in respiratory capacity, citrate synthase or succinate dehydrogenase activities, or in cytochrome c concentration in skeletal muscle in response to 6 wk of epinephrine treatment. These results are compatible with the suggestion that catecholamines may play a role in some of the metabolic and cardiac adaptations to exercise training. However, they argue strongly against the hypothesis that catecholamines are responsible for inducing the increase in muscle mitochondria that occurs in response to exercise training.