The inhibition of type I bacterial signal peptidase: Biological consequences and therapeutic potential
The inhibition of type I bacterial signal peptidase: Biological consequences and therapeutic potential
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DOI：
10.1016/j.bmcl.2015.07.072
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发表时间：
2015-11-01
影响因子：
2.7
通讯作者：
Romesberg, Floyd E.
中科院分区：
文献类型：
--
作者：
Craney, Arryn;Romesberg, Floyd E.
一般分泌途径一直被认为是潜在的抗生素药物靶点。特别是，细菌I型信号肽酶（SPase）正在成为治疗用途的强有力的候选者。在这篇综述中，我们重点介绍了使用SPase抑制剂作为原核生物学探针所获得的信息。彻底了解SPase抑制的后果和产生耐药性的机制对于SPase作为抗生素靶标的成功至关重要。除了SPase在加工分泌蛋白中的作用外，SPase抑制剂的使用还阐明了SPase在调节膜蛋白切割事件中的先前未知的功能。(C)2015爱思唯尔有限公司版权所有。
The general secretory pathway has long been regarded as a potential antibiotic drug target. In particular, bacterial type I signal peptidase (SPase) is emerging as a strong candidate for therapeutic use. In this review, we focus on the information gained from the use of SPase inhibitors as probes of prokaryote biology. A thorough understanding of the consequences of SPase inhibition and the mechanisms of resistance that arise are essential to the success of SPase as an antibiotic target. In addition to the role of SPase in processing secreted proteins, the use of SPase inhibitors has elucidated a previously unknown function for SPase in regulating cleavage events of membrane proteins. (C) 2015 Elsevier Ltd. All rights reserved.