Dynamic contrast-enhanced magnetic resonance imaging at 1.5 Tesla with gadopentetate dimeglumine to assess the angiostatic effects of anginex in mice
Dynamic contrast-enhanced magnetic resonance imaging at 1.5 Tesla with gadopentetate dimeglumine to assess the angiostatic effects of anginex in mice
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DOI：
10.1016/j.ejca.2004.01.020
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发表时间：
2004-05-01
影响因子：
8.4
通讯作者：
Griffioen, AW
中科院分区：
文献类型：
--
作者：
de Lussanet, QG;Beets-Tan, RGH;Griffioen, AW
The purpose of this study was to evaluate the effects of anginex on tumour angiogenesis assessed by dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) on a clinical 1.5 Tesla MR system and with the clinically available contrast agent gadopentetate dimeglumine. C57BL/6 mice carrying B16F10 melanomas were treated with anginex, TNP-470 or saline. Tumour growth curves and microvessel density (MVD) were recorded to establish the effects of treatment. DCE-MRI was performed on day 16 after tumour inoculation, and the endothelial transfer coefficients of the microvessel permeability surface-area product (K-PS) were calculated using a two-compartment model. Both anginex and TNP-470 resulted in smaller tumour volumes (P < 0.0001) and lower MVD (P < 0.05) compared to saline. Treatment with anginex resulted in a 64% reduction (P < 0.01) of tumour K-PS and TNP-470 resulted in a 44% reduction (P = 0.17), compared to saline. DCE-MRI with a clinically available, small-molecular contrast agent can therefore be used to evaluate the angiostatic effects of anginex and TNP-470 on tumour angiogenesis. (C) 2004 Elsevier Ltd. All rights reserved.
