Daedalols A-C, fungal-derived BACE1 inhibitors.
Daedalols A-C, fungal-derived BACE1 inhibitors.
复制标题
Daedalols A-C，真菌衍生的 BACE1 抑制剂。
DOI：
10.1016/j.bmc.2011.09.029
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发表时间：
2011
影响因子：
3.5
通讯作者：
Williams,PhilipG
中科院分区：
文献类型：
--
作者：
Sorribas,Analia;Jimenez,JorgeI;Yoshida,WesleyY;Williams,PhilipG
Bioassay-guided fractionation of an extract prepared from the fruiting bodies of a Daedalea sp. has led to the isolation of daedalols A–C (1–3). The structures of these new triterpenes were elucidated based on extensive NMR spectroscopic and mass spectrometric measurements. Assignment of the relative configuration of 3 required the preparation of a suitable derivative via a Payne rearrangement. The aspartic protease BACE1, an Alzheimer’s drug target, was inhibited by 3 with an IC50value of 14.2μM.
