Postoperative adjuvant and salvage radiotherapy for prostate cancer: Impact on freedom from biochemical relapse and survival
Postoperative adjuvant and salvage radiotherapy for prostate cancer: Impact on freedom from biochemical relapse and survival
复制标题
DOI：
10.1016/j.urology.2004.06.020
复制
发表时间：
2004-11-01
期刊：
影响因子：
2.1
通讯作者：
Zlotecki, RA
中科院分区：
文献类型：
--
作者：
Pacholke, HD;Wajsman, Z;Zlotecki, RA
目标。目的探讨高危前列腺癌根治性前列腺切除术后辅助放疗或补救性放疗的治疗效果。1982年至2000年间，163例根治性前列腺切除术后患者接受了RT治疗。我们对107例术后不到1年的淋巴结阴性患者（T2-T4N0）进行了辅助治疗，对56例持续升高的前列腺特异性抗原水平、术后生化复发或局部复发的患者进行了挽救治疗。中位随访时间为70个月（2 - 167个月）。接受辅助放疗的患者比接受补救性放疗的患者出现生化复发的可能性更小。在第5年和第10年，辅助治疗组的生化复发率分别为80%和66%，而以挽救为目的的治疗组分别为39%和22%
Objectives. To determine the therapeutic outcomes in patients with high-risk prostate cancer treated with adjuvant or salvage radiotherapy (RT) after radical prostatectomy.Methods. Between 1982 and 2000, 163 patients were treated with RT after radical prostatectonny. Adjuvant therapy was administered to 107 consecutive node-negative patients (T2-T4N0) referred to our institution less than I year after surgery for postoperative RT. Salvage treatment was delivered to 56 patients for a persistently elevated prostate-specific antigen level, biochemical relapse after surgery, or local recurrence.Results. The median follow-up was 70 months (range 2 to 167) from the initiation of RT. Patients treated with adjuvant RT were less likely than those treated with salvage RT to experience biochemical relapse. At 5 and 10 years, the rate of freedom from biochemical relapse was 80% and 66% in the adjuvant cohort compared with 39% and 22% for patients treated with salvage intent, respectively (P