G protein-coupled cyclic AMP signaling in postmortem brain of subjects with mood disorders: Effects of diagnosis, suicide, and treatment at the time of death
G protein-coupled cyclic AMP signaling in postmortem brain of subjects with mood disorders: Effects of diagnosis, suicide, and treatment at the time of death
复制标题
DOI：
10.1046/j.1471-4159.1999.0731121.x
复制
发表时间：
1999-09-01
影响因子：
4.7
通讯作者：
Young, LT
中科院分区：
文献类型：
--
作者：
Dowlatshahi, D;MacQueen, GM;Young, LT
环磷酸腺苷（cAMP）信号的组件进行了检查，在死后的大脑皮层的一个良好的特征组的情绪障碍患者和非精神病对照组。我们测量了G蛋白水平，腺苷酸环化酶（AC）的活性，CREB水平在大脑皮层的主题方面的诊断，治疗和自杀。诊断对任何测量都没有影响，除了情绪障碍受试者相对于对照受试者刺激AC活动减少的趋势。我们还检测到自杀对因自杀而死亡的受试者的颞叶皮质CREB水平的显著影响，相对于那些没有自杀的受试者，这在重度抑郁症患者中更为明显。双相情感障碍（BD）受试者在死亡时接受抗惊厥药物治疗，相对于未接受抗惊厥药物治疗的受试者，其颞叶皮质CREB水平降低。此外，我们发现在接受锂治疗的艾德受试者中，枕叶皮质G α（s）（短）水平有下降的趋势。这些结果支持了心境障碍中cAMP信号改变的假设，并提出了诊断以外的因素（如治疗和自杀）可能与文献中报道的细胞信号异常相关的可能性。
Components of cyclic AMP (cAMP) signaling were examined in postmortem cerebral cortex of a well characterized group of patients with mood disorders and nonpsychiatric control subjects. We measured G protein levels, adenylyl cyclase (AC) activity, and CREB levels in cerebral cortex of the subjects with respect to diagnosis, treatment, and suicide. There was no effect of diagnosis on any measure, except for a trend toward decreased stimulated AC activity in subjects with mood disorders relative to control subjects. We also detected a significant effect of suicide on temporal cortex CREB levels in subjects that died as a result of suicide relative to those that did not, which was more evident in patients with major depressive disorder. Bipolar disorder (BD) subjects treated with anticonvulsants at the time of death had decreased temporal cortex CREB levels relative to those not receiving anticonvulsants. Furthermore, we found a trend toward decreased occipital cortex G alpha(s) (short) levels in ED subjects treated with lithium. These results support the hypothesis of altered cAMP signaling in mood disorders and raise the possibility that factors other than diagnosis, such as treatment and suicide, may be relevant to cell-signaling abnormalities reported in the literature.