All-in-One, Wireless, Stretchable Hybrid Electronics for Smart, Connected, and Ambulatory Physiological Monitoring
All-in-One, Wireless, Stretchable Hybrid Electronics for Smart, Connected, and Ambulatory Physiological Monitoring
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DOI：
10.1002/advs.201900939
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发表时间：
2019-09-01
期刊：
影响因子：
15.1
通讯作者：
Yeo, Woon-Hong
中科院分区：
文献类型：
--
作者：
Kim, Yun-Soung;Mahmood, Musa;Yeo, Woon-Hong
市售的健康监视器依赖于刚性电子外壳，其与侵蚀性粘合剂和导电凝胶结合，导致不适并引起皮肤损伤。此外，研究级的皮肤可穿戴设备虽然在某些方面表现出色，但由于主动无线通信和集成为单个设备平台的根本挑战，其仅作为概念展示而不足。在这里，介绍了一种一体化的无线可伸缩混合电子设备，具有实时生理监测的关键功能，通过深度学习自动检测信号异常，以及远程无线连接（高达15 m）。薄膜电子层与超弹性弹性体的战略集成允许整个设备与人体自然粘附和变形，同时保持板载电子器件的功能。可拉伸电极具有针对亲密皮肤接触的优化结构，能够生成临床级心电图，并在运动传感器评估身体活动时准确分析心率和呼吸率。用于实时生理分类的卷积神经网络的实现证明了具有高度临床相关性的多方面分析的可行性。最后，动物和人类受试者在各种情况下的体内演示揭示了该设备作为健康监测器和可行的研究工具的多功能性。
Commercially available health monitors rely on rigid electronic housing coupled with aggressive adhesives and conductive gels, causing discomfort and inducing skin damage. Also, research-level skin-wearable devices, while excelling in some aspects, fall short as concept-only presentations due to the fundamental challenges of active wireless communication and integration as a single device platform. Here, an all-in-one, wireless, stretchable hybrid electronics with key capabilities for real-time physiological monitoring, automatic detection of signal abnormality via deep-learning, and a long-range wireless connectivity (up to 15 m) is introduced. The strategic integration of thin-film electronic layers with hyperelastic elastomers allows the overall device to adhere and deform naturally with the human body while maintaining the functionalities of the on-board electronics. The stretchable electrodes with optimized structures for intimate skin contact are capable of generating clinical-grade electrocardiograms and accurate analysis of heart and respiratory rates while the motion sensor assesses physical activities. Implementation of convolutional neural networks for real-time physiological classifications demonstrates the feasibility of multifaceted analysis with a high clinical relevance. Finally, in vivo demonstrations with animals and human subjects in various scenarios reveal the versatility of the device as both a health monitor and a viable research tool.