Transcription from the gene encoding the herpesvirus entry receptor nectin-1 (HveC) in nervous tissue of adult mouse
Transcription from the gene encoding the herpesvirus entry receptor nectin-1 (HveC) in nervous tissue of adult mouse
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DOI：
10.1006/viro.2001.1041
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发表时间：
2001-09-01
期刊：
影响因子：
3.7
通讯作者：
Spear, PG
中科院分区：
文献类型：
--
作者：
Haarr, L;Shukla, D;Spear, PG
人和小鼠形式的Nectin-1(HveC，Prr1)都可以作为多种嗜神经性疱疹病毒的进入受体，包括单纯疱疹病毒1和2(HSV-1，HSV-2)，猪伪狂犬病病毒(PRV)和牛疱疹病毒1。HSV-1，HSV-2和PRV可以引起小鼠致命的神经系统疾病，无论是直接接种到中枢神经系统还是通过外周途径接种。用原位杂交法检测Nectin-1在成年小鼠神经系统细胞中的表达。在周围神经系统的感觉神经节、交感神经节和副交感神经节的神经元中检测到了特异的杂交信号。此外，在脊髓腹角和背角以及脑干、小脑、大脑皮层、海马体、齿状回和嗅球的神经元中也观察到了特定的信号。这些结果表明，Nectin-1基因在成年小鼠的神经元中广泛转录。Nectin-1是已知的唯一能够介导HSV-1、HSV-2和PRV这三种病毒进入的受体。它在神经系统中的表达模式表明，它在这些病毒引起的神经系统疾病中发挥了关键作用。(C)2001年学术出版社。
Both human and murine forms of nectin-1 (HveC, Prr1) can serve as entry receptors for several neurotropic herpesviruses, including herpes simplex viruses 1 and 2 (HSV-1, HSV-2), porcine pseudorabies virus (PRV), and bovine herpesvirus 1. HSV-1, HSV-2, and PRV can cause lethal neurological disease in mice whether inoculation is directly Into the central nervous system or by peripheral routes. Expression of nectin-1 transcripts in cells of the adult mouse nervous system was assessed by in situ hybridization. Specific hybridization signals were detected in neurons in sensory, sympathetic, and parasympathetic ganglia of the peripheral nervous system. In addition, specific signals were observed in neurons of the ventral and dorsal horns of the spinal cord and of the brain stem, cerebellum, cerebral cortex, hippocampus, dentate gyrus, and olfactory bulb. These results show that the nectin-1 gene is widely transcribed in neurons in adult mouse. Nectin-1 is the only known receptor capable of mediating the entry of all three viruses, HSV-1, HSV-2, and PRV. Its pattern of expression in the nervous system suggests a key role in neurological disease caused by these viruses. (C) 2001 Academic Press.