Long non-coding RNAs in colorectal cancer.
Long non-coding RNAs in colorectal cancer.
复制标题
结直肠癌中的长非编码RNA
DOI：
10.18632/oncotarget.6446
复制
发表时间：
2016-02-02
期刊：
影响因子：
--
通讯作者：
Yang SM
中科院分区：
文献类型：
--
作者：
Xie X;Tang B;Xiao YF;Xie R;Li BS;Dong H;Zhou JY;Yang SM
结直肠癌（CRC）是全球癌症相关死亡的主要原因之一。尽管近年来在理解CRC的分子机制和治疗方面取得了实质性进展，但CRC患者的总体生存率并未显着提高。结直肠癌的发生发展是一个多因素、多步骤的过程，其中基因表达异常可能起重要作用。随着人类肿瘤分子生物学研究的深入，一系列研究表明长链非编码RNA（lncRNA）在结直肠癌发生发展中的作用。CRC相关的lncRNA已被证明通过多种机制调节基因，包括表观遗传修饰、lncRNA-miRNA和lncRNA-protein相互作用，以及通过它们作为miRNA前体或假基因的作用。由于一些lncRNA可以在人体体液中检测到，并且具有良好的特异性和可及性，它们已被建议用作CRC诊断和预后以及预测对治疗的反应的新的潜在生物标志物。因此，本文就lncRNA在结直肠癌发生发展中的作用、作用机制及其生物标志物的研究进展作一综述。
Colorectal cancer (CRC) is one of the leading causes of cancer-related death worldwide. Despite substantial progress in understanding the molecular mechanisms and treatment of CRC in recent years, the overall survival rate of CRC patients has not improved dramatically. The development of CRC is multifactor and multistep processes, in which abnormal gene expression may play an important role. With the advance of human tumor molecular biology, a series of studies have highlighted the role of long non-coding RNAs (lncRNAs) in the development of CRC. CRC-related lncRNAs have been demonstrated to regulate the genes by various mechanisms, including epigenetic modifications, lncRNA-miRNA and lncRNA-protein interactions, and by their actions as miRNA precursors or pseudogenes. Since some lncRNAs can be detected in human body fluid and have good specificity and accessibility, they have been suggested to be used as novel potential biomarkers for CRC diagnosis and prognosis as well as in the prediction of the response to therapy. Therefore, in this review, we will focus on lncRNAs in CRC development, the mechanisms and biomarkers of lncRNAs in CRC.