Intravascular forward-looking ultrasound transducers for microbubble-mediated sonothrombolysis.
Intravascular forward-looking ultrasound transducers for microbubble-mediated sonothrombolysis.
复制标题
DOI：
10.1038/s41598-017-03492-4
复制
发表时间：
2017-06-14
影响因子：
4.6
通讯作者：
Jiang X
中科院分区：
文献类型：
--
作者：
Kim J;Lindsey BD;Chang WY;Dai X;Stavas JM;Dayton PA;Jiang X
在急性血栓闭塞性疾病的临床治疗中，有效地清除或溶解大的血栓仍然是一个挑战。在这里，我们报道了一种血管内微泡介导的超声溶栓装置的开发，以提高溶栓率，从而最大限度地减少溶栓药物的需要剂量。我们假设，与传统的高频、侧视、导管安装的换能器相比，带有集成微泡注射管的亚兆赫前视超声换能器通过增强空化诱导的微流来更有利于有效的血栓溶解。我们开发了定制的微型换能器，并证明了这些换能器能够产生足够的压力来诱导脂壳微泡造影剂的空化。我们的技术显示，在不使用任何溶栓药物的情况下，体外溶栓率为0.7MJ±0.15% ± 0.15%。
Effective removal or dissolution of large blood clots remains a challenge in clinical treatment of acute thrombo-occlusive diseases. Here we report the development of an intravascular microbubble-mediated sonothrombolysis device for improving thrombolytic rate and thus minimizing the required dose of thrombolytic drugs. We hypothesize that a sub-megahertz, forward-looking ultrasound transducer with an integrated microbubble injection tube is more advantageous for efficient thrombolysis by enhancing cavitation-induced microstreaming than the conventional high-frequency, side-looking, catheter-mounted transducers. We developed custom miniaturized transducers and demonstrated that these transducers are able to generate sufficient pressure to induce cavitation of lipid-shelled microbubble contrast agents. Our technology demonstrates a thrombolysis rate of 0.7 ± 0.15 percent mass loss/min in vitro without any use of thrombolytic drugs.