Clinical presentations, diagnosis, and prognostic factors of bacterial meningitis
Clinical presentations, diagnosis, and prognostic factors of bacterial meningitis
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DOI：
10.1016/s0891-5520(05)70095-7
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发表时间：
1999-09-01
影响因子：
4.4
通讯作者：
Kaplan, SL
中科院分区：
文献类型：
--
作者：
Kaplan, SL
在过去的几十年里，儿童和成人细菌性脑膜炎的临床表现没有改变，高度怀疑对于及时识别感染患者仍然至关重要。随着流感嗜血杆菌B型脑膜炎（HiB）在常规施用HiB结合疫苗的世界地区的实际消失，用于快速检测细菌多糖的市售测试的效用已经降低。在脑脊液或血液中检测脑膜病原体的基因产物仍处于试验阶段。近期研究的预后结果与先前描述的结果并无不同，尽管重症患者的支持性护理取得了进展。
The clinical presentations of children and adults with bacterial meningitis have not changed over the past several decades, and a high index of suspicion remains critical for timely identification of infected patients. With the virtual disappearance of H, influenzae type B meningitis (Hib) in areas of the world where Hib conjugate vaccine is administered routinely, the utility of commercially available tests for rapid detection of bacterial polysaccharides has diminished. Detection of gene products of meningeal pathogens in cerebrospinal fluid or blood is still experimental. The prognostic findings of recent studies are not different from those previously described, despite advances in the supportive care of critically ill patients.