Secret signatures inside genomic DNA
Secret signatures inside genomic DNA
复制标题
DOI：
10.1021/bp049917i
复制
发表时间：
2004-09-01
影响因子：
2.9
通讯作者：
Ohashi, Y
中科院分区：
文献类型：
--
作者：
Arita, M;Ohashi, Y
介绍了一种简单实用的在基因组DNA中嵌入短商标或签名的方法。由于标记方法在生物学上是无害的，它可以应用于所有商业化的细菌，以帮助建立工程菌株的品牌名称，并解决有关基因相关专利的法律的纠纷。第一个这样的枯草芽孢杆菌菌株经过工程改造，并准备分发。
A simple, practical method to watermark short trademarks or signatures into genomic DNA is introduced. Since the marking method is biologically innocuous, it can be applied to all commercialized bacteria to help establish brand names for the engineered strains and to resolve legal disputes regarding gene-related patents. The first such strain of Bacillus subtilis is engineered and is ready to be distributed.