p53 on the crossroad between regeneration and cancer.
p53 on the crossroad between regeneration and cancer.
复制标题
p53在再生和癌症之间的十字路口。
DOI：
10.1038/cdd.2016.117
复制
发表时间：
2017-01
影响因子：
12.4
通讯作者：
Rotter V
中科院分区：
文献类型：
--
作者：
Charni M;Aloni-Grinstein R;Molchadsky A;Rotter V
再生和肿瘤发生具有共同的分子途径，然而再生的结果是生命，而肿瘤发生导致死亡。虽然再生过程受到严格控制，但恶性转化是不受限制的。在这篇综述中，我们讨论了TP53，主要的肿瘤抑制基因，在再生过程中的参与。我们指出p53作为协调者的作用，确保再生不会转变为致癌作用。再生过程中p53活性的波动允许严格控制。一方面，其在初始阶段的抑制允许大量增殖，另一方面，其在再生的高级步骤的诱导对于保持再生过程的稳健性和保真度是必不可少的。更好地了解p53在再生调控中的作用，可能会为在再生医学中实施目前可用于癌症患者的基于TP53的疗法提供新的机会。
Regeneration and tumorigenesis share common molecular pathways, nevertheless the outcome of regeneration is life, whereas tumorigenesis leads to death. Although the process of regeneration is strictly controlled, malignant transformation is unrestrained. In this review, we discuss the involvement of TP53, the major tumor-suppressor gene, in the regeneration process. We point to the role of p53 as coordinator assuring that regeneration will not shift to carcinogenesis. The fluctuation in p53 activity during the regeneration process permits a tight control. On one hand, its inhibition at the initial stages allows massive proliferation, on the other its induction at advanced steps of regeneration is essential for preservation of robustness and fidelity of the regeneration process. A better understanding of the role of p53 in regulation of regeneration may open new opportunities for implementation of TP53-based therapies, currently available for cancer patients, in regenerative medicine.