Where am I now? Distinct roles for parahippocampal and retrosplenial cortices in place recognition
Where am I now? Distinct roles for parahippocampal and retrosplenial cortices in place recognition
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DOI：
10.1523/jneurosci.0799-07.2007
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发表时间：
2007-06-06
影响因子：
5.3
通讯作者：
Feiler, Alana M.
中科院分区：
文献类型：
--
作者：
Epstein, Russell A.;Parker, Whitney E.;Feiler, Alana M.
空间导航的一个关键组成部分是使用视觉信息来确定自己的位置以及自己在世界上的方向的能力。我们使用功能性磁共振成像来检查人类这种现象的神经关联。研究人员对受试者进行扫描，同时对不同的地形和非地形信息进行检索。在三个关键条件下，他们观看熟悉的大学校园的图像，并报告图像中所描绘的地方的位置（定位任务），相机拍摄图像时面对的指南针方向（定位任务），或者该位置是否在校园内（熟悉任务）。我们的分析主要集中在脾后皮质(RSC)/顶枕沟区和海马旁位置区（PPA），这些区域在位置识别中起着关键作用。RSC活动取决于所检索信息的类型，在定位任务中反应最强。相比之下，PPA活性不依赖于检索任务。进一步的分析显示，熟悉度对RSC的影响很大，但对PPA的影响不大，前者对熟悉校园的图像的反应要比对不熟悉校园的图像强烈得多。这些结果表明，PPA和RSC在位置识别中发挥着不同但互补的作用。特别是，PPA可能主要支持对即时场景的感知，而RSC可能支持记忆检索机制，使场景在更广泛的空间环境中定位。
A key component of spatial navigation is the ability to use visual information to ascertain where one is located and how one is oriented in the world. We used functional magnetic resonance imaging to examine the neural correlates of this phenomenon in humans. Subjects were scanned while retrieving different kinds of topographical and nontopographical information in response to visual scenes. In the three critical conditions, they viewed images of a familiar college campus, and reported either the location of the place depicted in the image (location task), the compass direction that the camera was facing when the image was taken (orientation task), or whether the location was on campus or not (familiarity task). Our analyses focused on the retrosplenial cortex (RSC)/parietal-occipital sulcus region and the parahippocampal place area (PPA), which previous studies indicate play a critical role in place recognition. RSC activity depended on the type of information retrieved, with the strongest response in the location task. In contrast, PPA activity did not depend on the retrieval task. Additional analyses revealed a strong effect of familiarity in RSC but not in the PPA, with the former region responding much more strongly to images of the familiar campus than to images of an unfamiliar campus. These results suggest that the PPA and RSC play distinct but complementary roles in place recognition. In particular, the PPA may primarily support perception of the immediate scene, whereas RSC may support memory retrieval mechanisms that allow the scene to be localized within the broader spatial environment.