Obesity and mental health improvement following nutritional education focusing on gut microbiota composition in Japanese women: a randomised controlled trial
Obesity and mental health improvement following nutritional education focusing on gut microbiota composition in Japanese women: a randomised controlled trial
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日本女性肠道微生物群组成的营养教育改善肥胖和心理健康：一项随机对照试验
DOI：
10.1007/s00394-018-1873-0
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发表时间：
2018
影响因子：
5
通讯作者：
Ohira Tetsuya
中科院分区：
文献类型：
--
作者：
Uemura Mayu;Hayashi Fumikazu;Ishioka Ken;Ihara Kunio;Yasuda Kazushi;Okazaki Kanako;Omata Junichi;Suzutani Tatsuo;Hirakawa Yoshihisa;Chiang Chifa;Aoyama Atsuko;Ohira Tetsuya
目的胃肠道微生物区系组成可能与肥胖和心理因素有关。我们研究了以肠道微生物区系组成为重点的营养教育干预对肥胖女性肥胖和心理因素的影响。方法44名40岁及以上的日本肥胖女性随机分为干预组(n= 22)和对照组(n= 22)。干预包括20分钟的饮食讲座和10分钟的注册营养师咨询会议，连续8周，每2周一次。干预前后测量体重、身高、腰围、食物频度和肠道微生物区系组成，并对自测的健康和心理因素进行评分。干预后干预组膳食纤维摄入量(p<； )、蔬菜摄入量(p= 0.020)、奶及奶制品摄入量(p<； )均显著高于对照组。体重和体重指数(BMI；p<； 0.001)、腰围(p<； 0.0 1)和抑郁量表评分(p<； 0.0 1)显著下降，自评健康(p= 0.045)和微生物群多样性(p<； 0.0 1)显著改善。结论以肠道微生物区系组成为重点的营养教育可改善肥胖妇女的肥胖和心理因素。
PurposeGut microbiota composition was supposedly related to obesity and psychological factors. We examined the effects of a nutritional education intervention focusing on gut microbiota composition on obesity and psychological factors among obese women.MethodsForty-four obese Japanese women aged 40 or older were randomly assigned to either an intervention group (n= 22) or control group (n= 22). The intervention consisted of a 20-min dietary lecture and a 10-min counselling session by registered dieticians, every 2 weeks for eight consecutive weeks. Body weight, height, waist circumference, food frequency, and gut microbiota composition were measured, and self-rated health and psychological factors were scored before and after the intervention.ResultsAll participants completed the 8 week program. After the intervention, dietary fibre intake (p< 0.01), frequency of vegetable consumption (p= 0.020), and frequency of milk and milk product consumption (p< 0.01) increased significantly in the intervention group compared with the control group. Body weight and body mass index (BMI;p< 0.001), waist circumference (p< 0.01), and the depression scale score (p< 0.01) decreased significantly, while significant improvements were found in self-rated health (p= 0.045) and microbiome diversity (p< 0.01).ConclusionNutritional education focusing on gut microbiota composition may improve obesity and psychological factors in obese women.