Postdeposition Dispersion of Aerosol Medications Using Surfactant Carriers
Postdeposition Dispersion of Aerosol Medications Using Surfactant Carriers
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DOI：
10.1089/jamp.2008.0699
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发表时间：
2008-12-01
影响因子：
3.4
通讯作者：
Corcoran, Timothy E.
中科院分区：
文献类型：
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作者：
Marcinkowski, Amy L.;Garoff, Stephen;Corcoran, Timothy E.
吸入气雾剂药物提供了一种直接治疗肺部的方法；然而，气溶胶沉积和药物分布可能不均匀，尤其是在阻塞性肺疾病中。我们假设基于表面活性剂的气溶胶载体在沉积后通过表面张力驱动的流动将药物分散在气道表面，增加剂量均匀性并改善药物在通风不良区域的分布。我们考虑通过套管将盐水和表面活性剂气雾剂输送到几种模型气道表面，包括猪胃粘液（PGM）以及囊性纤维化（CF）和非CF人支气管上皮细胞（HBE）。使用荧光染料和微球（d = 100 nm，1 μm）对沉积后分散进行定性和定量评估。气溶胶体积中值直径在1-4μm范围内。测试的表面活性剂包括十二烷基硫酸钠 (SIDS)、十六烷基三甲基溴化铵 (CTAB)、泰洛沙泊和 calfactant。与所有标记物的盐水相比，在 PGM（泰洛沙泊、calfactant、SDS 和 CTAB）上测试的所有表面活性剂均显着增加了分散面积（增加 2-20 倍；所有 p < 0.04）。与使用所有标记物的盐水相比，在 CF HBE（泰洛沙泊和 calfactant）上测试的两种表面活性剂均显着增加了分散面积（增加 1.6-4.1 倍；所有 p
Inhaled aerosol drugs provide a means of directly treating the lungs; however, aerosol deposition and drug distribution can be nonuniform, especially in obstructive lung disease. We hypothesize that surfactant-based aerosol carriers will disperse medications over airway surfaces after deposition through surface tension driven flows, increasing dose uniformity and improving drug distribution into underventilated regions. We considered saline and surfactant aerosol delivery via cannula onto several model airway Surfaces including porcine gastric mucus (PGM) and both cystic fibrosis (CF) and non-CF human bronchial epithelial cells (HBEs). Fluorescent dye and microspheres (d = 100 nm, 1 mu m) were used to qualitatively and quantitatively assess post-deposition dispersion. Aerosol volume median diameters were in the 1-4 mu m range. The tested surfactants included sodium dodecyl sulfate (SIDS), cetyl trimethyl ammonium bromide (CTAB), tyloxapol, and calfactant. All surfactants tested on PGM (tyloxapol, calfactant, SDS, and CTAB) significantly increased dispersion area versus saline with all markers (2-20-fold increases; all p < 0.04). Both surfactants tested on CF HBEs (tyloxapol and calfactant) significantly increased dispersion area versus saline with all markers (1.6-4.1-fold increases; all p