Rate versus synchrony codes for cerebellar control of motor behavior.
Rate versus synchrony codes for cerebellar control of motor behavior.
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小脑控制运动行为的速率与同步代码。
DOI：
10.1101/2023.02.17.529019
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发表时间：
2023
期刊：
影响因子：
--
通讯作者：
Lisberger,StephenG
中科院分区：
文献类型：
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作者：
Herzfeld,DavidJ;Joshua,Mati;Lisberger,StephenG
神经群体之间的信息传输可以通过放电率的协调变化或尖峰时间的精确传输来进行。我们调查的代码从小脑皮层的一部分，这是至关重要的准确执行可量化的运动行为的信息传输。来自恒河猴小脑中浦肯野细胞对的同步记录揭示了这些细胞如何协调它们的活动以驱动平滑的追踪眼球运动。浦肯野细胞表现出毫秒级的尖峰协调（同步），但同步水平很小，不足以影响下游前庭核神经元的放电。对先前旨在揭示浦肯野细胞同步性的指标的分析表明，这些指标合并了放电率和神经元-神经元协方差的变化。我们的结论是，小脑皮质的输出主要使用速率而不是同步代码来驱动下游神经元的活动，从而控制运动行为。
Information transmission between neural populations could occur through either coordinated changes in firing rates or the precise transmission of spike timing. We investigate the code for information transmission from a part of the cerebellar cortex that is crucial for the accurate execution of a quantifiable motor behavior. Simultaneous recordings from Purkinje cell pairs in the cerebellum of rhesus macaques reveal how these cells coordinate their activity to drive smooth pursuit eye movements. Purkinje cells show millisecond-scale coordination of spikes (synchrony), but the level of synchrony is small and insufficient to impact the firing of downstream vestibular nucleus neurons. Analysis of previous metrics that purported to reveal Purkinje cell synchrony demonstrates that these metrics conflate changes in firing rate and neuron-neuron covariance. We conclude that the output of the cerebellar cortex uses primarily a rate rather than a synchrony code to drive the activity of downstream neurons and thus control motor behavior.