Impaired lymphocyte function in aged humans.
Impaired lymphocyte function in aged humans.
复制标题
老年人淋巴细胞功能受损。
DOI：
--
复制
发表时间：
1974
影响因子：
15.9
通讯作者：
T. Hütteroth
中科院分区：
文献类型：
--
作者：
M. Weksler;T. Hütteroth
测定了年轻人和老年人的淋巴细胞对植物血凝素、商陆有丝分裂原或同种异体淋巴细胞的反应。与年轻人的淋巴细胞相比，老年人的淋巴细胞在植物有丝分裂原或同种异体细胞培养中掺入的氚胸腺嘧啶核苷显著减少。观察到的淋巴细胞反应性的差异不能归因于老年人和年轻人淋巴细胞最大转化所需的培养条件的不同。在老年人和年轻人的血液中，发现胸腺来源的淋巴细胞和骨髓来源的淋巴细胞的比例相同。对这些发现与免疫能力随年龄下降的关系进行了讨论。
The response of lymphocytes from young and old persons to phytohemagglutinin, pokeweed mitogen, or allogeneic lymphocytes has been measured. Lymphocytes from old persons incorporated significantly less tritiated thymidine as compared with lymphocytes from young persons when cultured with plant mitogens or allogeneic cells. The difference in observed lymphocyte reactivity could not be attributed to differences in culture conditions required for maximal transformation of lymphocytes from old or young subjects. The same percentage of thymus-derived and bone marrow-derived lymphocytes was found in the blood from old and young persons. The relationship of these findings to the decline of immunologic competence with age is discussed.