Evaluation of selected Sudanese medicinal plants for their in vitro activity against hemoflagellates, selected bacteria, HIV-1-RT and tyrosine kinase inhibitory, and for cytotoxicity
Evaluation of selected Sudanese medicinal plants for their in vitro activity against hemoflagellates, selected bacteria, HIV-1-RT and tyrosine kinase inhibitory, and for cytotoxicity
复制标题
DOI：
10.1016/s0378-8741(02)00245-3
复制
发表时间：
2002-12-01
影响因子：
5.4
通讯作者：
Kaminsky, R
中科院分区：
文献类型：
--
作者：
Ali, H;König, GM;Kaminsky, R
通过民族植物学调查，选择了苏丹传统上用于抗击疟疾和其他类似热带疾病的19种植物进行进一步研究。Pamianthe peruviana(石蒜科)对氯喹抗性恶性疟原虫株(K1)和氯喹敏感株(NF54)有显著的抑制作用，IC50值分别为0.6和1.1µg/ml。另外，苏云金杆菌对布氏锥虫和克氏锥虫均有较强的杀灭活性，IC50分别为1.5和11.8。不同提取物对恶性疟原虫NF54株的抑制率分别为0.6µg/ml(茎)和0.7µg/ml(叶)。鸡冠花不同部位提取物对恶性疟原虫氯喹敏感株(NF54)有明显的抑制作用，其IC50值分别为0.2mug/ml(树皮)、0.4mug/ml(茎)和4.3mug/ml(叶)。最有趣的是，在66µg/ml的浓度下，哈特曼纳叶提取物完全抑制HIV-1逆转录酶(HIV-1 RT)。该提取物对p56(Lck)酪氨酸激酶也有较强的抑制作用。(C)2002爱思唯尔科学爱尔兰有限公司。保留所有权利。
Ethnobotanical investigations led to the selection of 19 plant species, used traditionally in Sudan against malaria and other similar tropical diseases, for further studies. Pamianthe peruviana (Amaryllidaceae) exhibited significant activity against a chloroquine-resistant Plasmodium falciparum strain (K1) and a chloroquine-sensitive strain (NF54) with IC50 values of 0.6 and 1.1 mug/ml, respectively. Additionally, P. peruviana showed considerable activities against Trypanosoma brucei rhodesiense (IC50 1.5 mug/ml) and T cruzi (IC50 11.8 mug/ml). The antiplasmodial activity of the different extracts of Salvadora persica (Salvadoraceae) against P. falciparum NF54 strain were found to be 0.6 mug/ml (stems) and 0.7 mug/ml (leaves). Extracts of different parts of Combretum hartmannianum (Combretaceae) possessed significant activity against the chloroquine-sensitive P. falciparum strain (NF54) with IC50 values of 0.2 mug/ml (bark), 0.4 mug/ml (stem) and 4.3 mug/ml (leaves). Most interestingly, the extracts of the leaves of C hartmannianum totally inhibited the enzyme HIV-1 reverse transcriptase (HIV-1 RT) at a concentration of 66 mug/ml. A comparably strong activity against p56(lck) tyrosine kinase was also seen for this extract. (C) 2002 Elsevier Science Ireland Ltd. All rights reserved.